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| Product Name: | Thiamine hydrochloride | Other Name: | Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,chloride,hydrochloride (1:1:1);Thiamine,monohydrochloride;Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,chloride,monohydrochloride;3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,β-hydroxyethylthiazolium chloride hydrochloride;Aneurine hydrochloride;Apate drops;Beatine;Bedome;Begiolan;Benerva;Bequin;Berin;Betabion;Betalin S;Betaxin;Bethiazine;Beuion;Bevitine;Bewon;Biuno;Bivatin;Bivita;Clotiamina;Eskapen;Eskaphen;Lixa-Beta;Metabolin;Slowten;THD;Thiadoxine;Thiaminal;Thiamine chloride hydrochloride;Thiamine dichloride;Thiamine hydrochloride;Thiamin hydrochloride;Thiaminium chloride;Thiaminium chloride hydrochloride;Thiamol;Thiavit;Tiamidon;Tiaminal;Trophite;Vetalin S;Vinothiam;Vitamin B1 hydrochloride;Vitaneuron;Thiamine chloride;Thiamin chloride;Thiamin dichloride;Biamine;3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium hydrochloride chloride;63-66-1;70732-86-4;108631-50-1;2173536-98-4;2227489-38-3 |
| CAS No.: | 67-03-8 | Molecular Formula: | C12H17N4OS.ClH.Cl |
| InChIKeys: | InChIKey=DPJRMOMPQZCRJU-UHFFFAOYSA-M | Molecular Weight: | 337.27 |
| Exact Mass: | 336.058 | BRN: | 3851771 |
| EC Number: | 200-641-8 | UNII: | M572600E5P |
| NSC Number: | 36226 | DSSTox ID: | DTXSID0040622 |
| NCI Thesaurus Code: | C48025 | Color/Form: | Crystals from water |
| HScode: | 29362200 | Categories: | Vitamins and Minerals Medicines |
| PSA: | 104 | XLogP3: | -1.00510 |
| Appearance: | White to almost white Crystalline Powder | Density: | 1.3766 (rough estimate) |
| Melting Point: | 248 °C (decomp) | Flash Point: | 100ºC |
| Water Solubility: | H2O: 0.1 g/mL at 20 °C, clear, colorless | Storage Conditions: | 2-8°C |
| Vapor Pressure: | 1.8X10-10 mm Hg at 25 deg C (est) | Toxicity: | LD50 in mice (mg/kg): 89.2 i.v.; 8224 orally (Winter) |
| Odor: | SLIGHT, CHARACTERISTIC | Experimental Properties: | Monoclinic plates in rosette-like clusters. Slight thiazole odor; bitter taste; decomposes at 248 °C. One gram dissolves in approximately 1 mL water, 18 mL glycerol, 100 mL 95% alcohol, 315 mL absolute alcohol; more soluble in methanol. Soluble in propylene glycol. Practically insoluble in ether, benzene, hexane, chloroform. pH of 1% wt/vol solution in water 3.13; pH of 0.1% wt/vol solution in water 3.58. On exposure to air of average humidity, the vitamin absorbs an amount of water corresponding to nearly one mole, forming a hydrate.|HYGROSCOPIC; NUT-LIKE ODOR /HYDROCHLORIDE/|READILY SPLIT BY SULFITE INTO ITS PYRIMIDINE & THIAZOLE CONSTITUENTS|Crystals. MP: 196-200 °C, decomposes; practically nonhygroscopic; pKa = 4.9. Solubility in water (g/100 mL): 2.7 (25 °C); approximately 30 (100 °C). pH of 2% aqueous solution 6.5 to 7.1, more stable than the hydrochloride; suitable for enrichment of flours and feeds, multivitamin preparations /Mononitrate/|SMALL WHITE CRYSTALS OR CRYSTALLINE POWDER /HYDROCHLORIDE/|Thiamine hydrochloride in the dry state is stable. Acidic solutions having a pH below 5.5 preferably from 5.0 to 3.5 are also relatively stable. Alkalies destroy it. It is precipitated from solution by several of the alkaloidal reagents such as mercuric chloride, iodine, picric acid, tannin, and Mayer’s reagent. It is sensitive to both oxidizing and reducing agents. /Hydrochloride/|For more Other Experimental Properties (Complete) data for Vitamin B1 (6 total), please visit the HSDB record page. |
Classification of the substance or mixture
Eye irritation, Category 2
GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word |
Warning |
| Hazard statement(s) |
H319 Causes serious eye irritation |
| Precautionary statement(s) | |
| Prevention |
P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/… |
| Response |
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Storage |
none |
| Disposal |
none |
Other hazards which do not result in classification
no data available
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.