L-Methionine | CAS 63-68-3 | Amino Acid for Food Fortification - - PREMIUM INGREDIENT

L-Methionine | CAS 63-68-3 | Amino Acid for Food Fortification, Food and Health Ingredients

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Amino Acids

CAS No:

63-68-3

3 / 1

Description

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Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

L-Methionine
CAS Number	63-68-3
Molecular Formula	C₅H₁₁NO₂S
Molecular Weight	149.21
Appearance	White crystalline powder or colorless transparent crystal
Purity Specification	99% Food Grade (High Purity)
Executive Standard	USP / CP /EP/AJI/FCC
Certifications	ISO, HALAL, KOSHER
Solubility	Soluble in water, slightly soluble in ethanol

Product Overview

L-Methionine, Cas No.: 63-68-3, is an essential sulfur-containing amino acid that human bodies cannot synthesize and must obtain from external intake. As a key nutritional fortifier for food, it is widely used in functional foods and dietary supplements. It acts as a precursor of glutathione, supporting liver metabolism and antioxidant protection to maintain normal human physiological function. Additionally, this ingredient also has large consumption in animal feed to balance amino acid nutrition for livestock. It can also be applied as raw material for high-purity clinical nutritional preparations.

Character

L-Methionine is a stable essential amino acid with regular white crystalline morphology and pure texture, possessing excellent water solubility and good compatibility with various food raw materials. The product has stable physical and chemical properties under conventional storage and processing conditions, no peculiar smell, and will not produce harmful substances during food thermal processing. Adopting advanced enzymatic transformation production technology, it avoids chemical solvent residue risks, conforms to international food safety specifications. With high purity and low impurity content, it can be fully absorbed and utilized by the human body, showing outstanding safety and applicability in food fortification and nutritional supplement formulas.

Main Functions

Essential Amino Acid Supplementation: As one of the indispensable amino acids for human growth and metabolism, L-Methionine effectively supplements daily amino acid deficiency, balances human nutritional structure, and improves the absorption and utilization efficiency of dietary protein.

Support Liver Metabolism and Antioxidation: It is an important synthetic precursor of glutathione, a key antioxidant in the human body. It assists liver detoxification and metabolic operation, reduces oxidative damage to human cells, and maintains liver health and normal metabolic circulation.

Food Nutritional Enhancement: It can fortify the amino acid nutrition of grain products, special meals and functional foods, make up for the nutritional defects of conventional daily diets, and improve the overall nutritional value of food products.

Maintain Human Physiological Balance: Participate in human protein synthesis and amino acid metabolism regulation, support normal body growth, tissue repair and physiological operation, and assist in maintaining body health stability.

Applications

Dietary Supplement: It is a classic raw material for amino acid nutritional supplements, widely used in compound amino acid tablets, capsules and powder formulas, targeting daily nutritional supplementation, physical conditioning and antioxidant health care for human body.

Food Industry: Serves as a professional food nutritional fortifier, commonly added in flour, cereal products, baked foods and special formula foods to optimize amino acid proportion and enhance the nutritional value of finished food products.

Animal Feed: Widely used as feed additive to supplement essential amino acids, balance feed nutrition, and promote the healthy growth of livestock.

Pharmaceutical Nutrition: High-purity food-grade L-Methionine can be used as auxiliary raw material for special medical nutritional formulas and compound amino acid preparations, providing safe and stable amino acid supplement for human clinical nutrition regulation.

Packaging and Storage

Packaging: 25kg /drum

Storage: Store in a dry, cool, ventilated and clean warehouse environment, avoid direct sunlight, high temperature and humid environment. Keep sealed during storage to prevent moisture absorption and agglomeration. Strictly store separately from toxic and harmful substances. The shelf life is 2 years under original packaging and qualified storage conditions。

Test item	specifications
Assay	98.5% to 101.5%
Identification	Infrared absorption
Specific rotation	+22.4° to +24.7°
PH	5.6 to 6.1
Loss on drying	Not more than 0.3%
Residue on ignition	Not more than 0.4%
Sulfate	Not more than 0.03%
Iron	Not more than 0.003%
Heavy metals	Not more than 0.0015%
Chromatographic purity	Not more than 0.5% of any individual impurity is found, and not more than 2.0% of total impurities is found
Organic volatile impurities	Meets the requirements
Chloride	Not more than 0.05%

Product Name:	l-Methionine	Other Name:	L-Methionine;Methionine,L-;Cymethion;Methionine;Butanoic acid,2-amino-4-(methylthio)-,(S)-;2-Amino-4-(methylthio)butyric acid;S-Methionine;α-Amino-γ-methylmercaptobutyric acid;γ-Methylthio-α-aminobutyric acid;(S)-2-Amino-4-(methylthio)butanoic acid;l-Methionine;L-α-Amino-γ-methylthiobutyric acid;L-Homocysteine,S-methyl-;h-Met-oh;Acimethin;NSC 22946;S-Methyl-L-homocysteine;Secretory peptide (human clone HTXDU73);Methiorep;Meth-o-Tas;(2S)-2-Azaniumyl-4-methylsulfanylbutanoate;(2S)-2-Amino-4-(methylsulfanyl)butanoic acid;7005-18-7;24425-78-3;1437749-32-0;1437749-60-4;1437749-65-9;1437749-75-1;1437749-80-8;1437769-00-0;1437870-94-4;1437870-95-5;1437870-97-7;1437870-98-8;1437871-20-9;1463481-01-7;1463481-06-2;1463481-15-3;1463481-19-7;1463481-23-3;1463481-27-7;1463481-31-3;1463481-37-9;1463481-41-5;1463481-46-0;1463481-51-7;1463481-58-4;1463481-73-3;1463481-80-2;1463481-89-1;1463610-75-4;1463610-76-5;1466415-57-5
CAS No.:	63-68-3	Molecular Formula:	C5H11NO2S
InChIKeys:	InChIKey=FFEARJCKVFRZRR-BYPYZUCNSA-N	Molecular Weight:	149.21100
Exact Mass:	149.21	EC Number:	200-562-9
UNII:	AE28F7PNPL	NSC Number:	760117
DSSTox ID:	DTXSID5040548	NCI Thesaurus Code:	C29600
Color/Form:	Minute hexagonal plates from dilute alcohol\|Colorless or white, lustrous plates or as white, crystalline powder	ATC Code:	V – Various
HScode:	2930400000	Categories:	Amino Acids and Derivatives

PSA:	88.62000	XLogP3:	-1.9
Appearance:	Minute hexagonal plates from dilute alcohol. (NTP, 1992)	Density:	1.206 g/cm3
Melting Point:	280-282 °C (decomp)	Boiling Point:	123-126 °C @ Press: 15 Torr
Flash Point:	139.4ºC	Refractive Index:	1.531
Water Solubility:	H2O: soluble	Storage Conditions:	Store at RT.
Vapor Pressure:	8.14X10-8 mm Hg at 25 deg C (est)	Toxicity:	LD50 oral in rat: 36gm/kg
Specific rotation:	Specific optical rotation: 22.5 deg at 25 °C/D (1 N HCl)	Odor:	Faint
Taste:	Sulfurous	PH:	pH (1% aqueous solution) = 5.6-6.1
PKA:	2.28(at 25 °C)	Henrys Law Constant:	Henry’s Law constant = 2.11X10-11 atm-cu m/mol at 25 °C (est)
Dissociation Constants:	2.28 (at 25 °C)\|pKa = 2.28; pK2 = 9.21	Collision Cross Section:	133.65 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]\|152.05 Å² [M-H]- [CCS Type: DT, Method: stepped-field]\|127 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]\|133.1 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|132 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|134.08 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]\|140.5 Å² [M-H]-
Experimental Properties:	Platelets from alcohol. mp 281 °C (decomposes), density 1.340; pKa1 = 2.28, pKa2 = 9.21; pH of 1% aqueous solution 5.6-6.1; Rf value 0.77. Solubility in water (g/L) at 0 °C: 18.18; at 25 °C: 33.81; at 50 °C: 60/.70; at 75 °C: 15.2 °C. Soluble in dilute acids, alkalies. Very slightly soluble in 95% alcohol. Insoluble in ether. /Methionine, DL-form/\|UV: 1-65 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York) /Methionine (DL)/\|Hydroxyl radical reaction rate constant = 5.13X10-11 cu cm/molec-sec at 25 °C (est)	Air and Water Reactions:	Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide (NTP, 1992). Water soluble (NTP, 1992). pH of 1% aqueous solution is 5.6-6.0.
Reactive Group:	Sulfides, Organic	Reactivity Profile:	An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. It is an amino acid essential in human nutrition.

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants. Well closed.