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| Product Name: | l-Methionine | Other Name: | L-Methionine;Methionine,L-;Cymethion;Methionine;Butanoic acid,2-amino-4-(methylthio)-,(S)-;2-Amino-4-(methylthio)butyric acid;S-Methionine;α-Amino-γ-methylmercaptobutyric acid;γ-Methylthio-α-aminobutyric acid;(S)-2-Amino-4-(methylthio)butanoic acid;l-Methionine;L-α-Amino-γ-methylthiobutyric acid;L-Homocysteine,S-methyl-;h-Met-oh;Acimethin;NSC 22946;S-Methyl-L-homocysteine;Secretory peptide (human clone HTXDU73);Methiorep;Meth-o-Tas;(2S)-2-Azaniumyl-4-methylsulfanylbutanoate;(2S)-2-Amino-4-(methylsulfanyl)butanoic acid;7005-18-7;24425-78-3;1437749-32-0;1437749-60-4;1437749-65-9;1437749-75-1;1437749-80-8;1437769-00-0;1437870-94-4;1437870-95-5;1437870-97-7;1437870-98-8;1437871-20-9;1463481-01-7;1463481-06-2;1463481-15-3;1463481-19-7;1463481-23-3;1463481-27-7;1463481-31-3;1463481-37-9;1463481-41-5;1463481-46-0;1463481-51-7;1463481-58-4;1463481-73-3;1463481-80-2;1463481-89-1;1463610-75-4;1463610-76-5;1466415-57-5 |
| CAS No.: | 63-68-3 | Molecular Formula: | C5H11NO2S |
| InChIKeys: | InChIKey=FFEARJCKVFRZRR-BYPYZUCNSA-N | Molecular Weight: | 149.21100 |
| Exact Mass: | 149.21 | EC Number: | 200-562-9 |
| UNII: | AE28F7PNPL | NSC Number: | 760117 |
| DSSTox ID: | DTXSID5040548 | NCI Thesaurus Code: | C29600 |
| Color/Form: | Minute hexagonal plates from dilute alcohol|Colorless or white, lustrous plates or as white, crystalline powder | ATC Code: | V – Various |
| HScode: | 2930400000 | Categories: | Amino Acids and Derivatives |
| PSA: | 88.62000 | XLogP3: | -1.9 |
| Appearance: | Minute hexagonal plates from dilute alcohol. (NTP, 1992) | Density: | 1.206 g/cm3 |
| Melting Point: | 280-282 °C (decomp) | Boiling Point: | 123-126 °C @ Press: 15 Torr |
| Flash Point: | 139.4ºC | Refractive Index: | 1.531 |
| Water Solubility: | H2O: soluble | Storage Conditions: | Store at RT. |
| Vapor Pressure: | 8.14X10-8 mm Hg at 25 deg C (est) | Toxicity: | LD50 oral in rat: 36gm/kg |
| Specific rotation: | Specific optical rotation: 22.5 deg at 25 °C/D (1 N HCl) | Odor: | Faint |
| Taste: | Sulfurous | PH: | pH (1% aqueous solution) = 5.6-6.1 |
| PKA: | 2.28(at 25 °C) | Henrys Law Constant: | Henry’s Law constant = 2.11X10-11 atm-cu m/mol at 25 °C (est) |
| Dissociation Constants: | 2.28 (at 25 °C)|pKa = 2.28; pK2 = 9.21 | Collision Cross Section: | 133.65 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|152.05 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|127 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|133.1 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|132 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|134.08 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|140.5 Ų [M-H]- |
| Experimental Properties: | Platelets from alcohol. mp 281 °C (decomposes), density 1.340; pKa1 = 2.28, pKa2 = 9.21; pH of 1% aqueous solution 5.6-6.1; Rf value 0.77. Solubility in water (g/L) at 0 °C: 18.18; at 25 °C: 33.81; at 50 °C: 60/.70; at 75 °C: 15.2 °C. Soluble in dilute acids, alkalies. Very slightly soluble in 95% alcohol. Insoluble in ether. /Methionine, DL-form/|UV: 1-65 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York) /Methionine (DL)/|Hydroxyl radical reaction rate constant = 5.13X10-11 cu cm/molec-sec at 25 °C (est) | Air and Water Reactions: | Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide (NTP, 1992). Water soluble (NTP, 1992). pH of 1% aqueous solution is 5.6-6.0. |
| Reactive Group: | Sulfides, Organic | Reactivity Profile: | An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. It is an amino acid essential in human nutrition. |
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word |
No signal word |
| Hazard statement(s) |
none |
| Precautionary statement(s) | |
| Prevention |
none |
| Response |
none |
| Storage |
none |
| Disposal |
none |
Other hazards which do not result in classification
no data available
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from strong oxidants. Well closed.