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Basic Information
Vitamin E Acetate
Product Type Fat-soluble vitamin acetate ester (stable form of Vitamin E)
Natural Form d‑Alpha Tocopheryl Acetate (Natural Vitamin E Acetate)
Synthetic Form dl‑Alpha Tocopheryl Acetate (Synthetic Vitamin E Acetate)
CAS No.  58-95-7 (Natural d‑α‑Tocopheryl Acetate)
CAS No.  7695-91-2 (Synthetic dl‑α‑Tocopheryl Acetate)
Available Forms Oil / Spray-dried Powder
Natural Raw Material Source

Soybean oil deodorizer distillate (primary)

sunflower oil deodorizer distillate (optional)

Synthetic Raw Material Source  (TMHQ + Isophytol)
Common Specifications Natural oil: 1000 IU/gSynthetic oil: 50%, 70%, 96% (1000 IU/g)Spray-dried powder: 50% CWS, 70% CWS
Product Color Reference

Oil: Clear pale yellow to golden viscous liquid

Powder: Off-white to pale yellow free-flowing powder

Production Method (Natural) Esterification of natural d-alpha tocopherol with acetic anhydride
Production Method (Synthetic) Chemical synthesis followed by acetylation

4 Types of Vitamin E Acetate Products 

 

Product Item Type 1: Natural Vitamin E Acetate Oil Type 2: Natural Vitamin E Acetate Powder Type 3: Synthetic Vitamin E Acetate Oil Type 4: Synthetic Vitamin E Acetate Powder
Physical Form Viscous oil Water dispersible spray-dried powder Viscous oil Water dispersible spray-dried powder
Common Spec 1000 IU/g 50% CWS, 70% CWS 50%, 70%, 96% (1000 IU/g) 50% CWS, 70% CWS
Bioactivity High biological activity Retains natural high activity Standard bioactivity Standard bioactivity
Core Feature Stable ester form, clean label, premium grade Natural source, stable, easy for solid formulation Cost-effective, highly stable, large supply Economical, convenient for premix
Typical Application Softgels, high-end cosmetics, premium supplements Tablets, hard capsules, instant powder drinks Mass softgels, food fortification, animal nutrition Tablets, feed premix, bulk functional powder
Solubility Oil-soluble Dispersible in water Oil-soluble Dispersible in water

 

Product Overview

 

Vitamin E acetate, also known as tocopheryl acetate, is the esterified derivative of vitamin E. It is supplied in both natural d-alpha-tocopheryl acetate and synthetic dl-alpha-tocopheryl acetate forms, available as oil and microencapsulated powder. Compared with free tocopherol, vitamin E acetate offers superior chemical stability, resisting oxidation during storage and processing. The natural form provides higher biological activity, while the synthetic form delivers stable supply with cost advantages. It serves as a stable nutrient ingredient for cosmetic and dietary supplement applications.

 

Compounding Characteristics

 

  • Oil form: Clear pale yellow to golden viscous liquid, nearly odorless
  •  
  • Spray-dried powder form: Off-white to pale yellow free-flowing powder
  •  
  • More stable than free tocopherol due to acetate ester protection
  •  
  • Oil grades are oil-soluble; spray-dried powder grades disperse in water
  •  
  • Sensitivity to heat, light and oxygen is lower than free tocopherol
  •  
  • Nitrogen-flushed sealed packaging recommended for long-term storage
  •  

Main Functions

 

1. Superior Chemical Stability: Esterified structure resists oxidative degradation, ensuring longer shelf life and lower processing loss compared with free tocopherol.

2. High Bioactivity Upon Release (Natural d-alpha-tocopheryl acetate): Natural vitamin E acetate hydrolyzes in the body or on skin to release active vitamin E, delivering higher biological activity than synthetic dl-alpha form.

3. Excellent Skin Compatibility: Smooth texture with good skin affinity, widely used in skincare and personal care formulations.

4. Convenient Dual Forms: Oil grade for liquid and emulsion systems; microencapsulated powder grade for tablets, hard capsules and solid beverages.

Applications

1.Cosmetic and Personal Care The largest application market for vitamin E acetate. Used in creams, lotions, serums, body care products and hair care formulations. It provides stable skin-nourishing and conditioning effects, with good compatibility in emulsion systems.

2.Dietary Supplements Used in softgels, tablets, hard capsules and solid beverage formulas. As a stable form of vitamin E, it reduces oxidation loss during product shelf life and serves as a nutritional ingredient for health supplement products.

 

Packaging & Storage

Packing: 25kg/drum (oil); 25kg/fiber drum (spray-dried powder)

Storage: Cool, dry, dark and ventilated environment, keep sealed under nitrogen

Shelf Life: 24 months under proper sealed storage

 

 

Product Name: Tocopheryl acetate Other Name: 2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,6-acetate,(2R)-;6-Chromanol,2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate,(+)-;2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-,acetate,[2R-[2R*(4R*,8R*)]]-;α-Tocopherol acetate;Vitamin E acetate;2H-1-Benzopyran-6-ol,3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-,acetate,(2R)-;(+)-α-Tocopherol acetate;d-α-Tocopheryl acetate;(+)-α-Tocopheryl acetate;α-Tocopheryl acetate;d-α-Tocopherol acetate;2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol acetate;Tocophrin;Fertilvit;Endo E Dompe;Gevex;Alfacol;Epsilan-M;E-Toplex;Evipherol;Econ;E-Ferol;Tocopherex;Tofaxin;Ephynal acetate;Contopheron;Ecofrol;Tokoferol acetate;Combinal E;Erevit;(2R,4′R,8′R)-α-Tocopheryl acetate;(R,R,R)-α-Tocopheryl acetate;Vitamin Eα acetate;(2R,4′R,8′R)-α-Tocopherol acetate;D-α-Tocopherol acetate;Covitol 1360;Tocopheryl acetate;Copherol 1250;Tocopherol acetate;Copherol 12250;D-α-Tocopheryl acetate;Covitol 1100;d-Vitamin E acetate;E-Vicotrat;Spondyvit;Tinoderm E;Nanotopes;Lutavit E 50;Covitol;E 230 Clear;Vitamin E 230 Clear;NatAc;Natur-E granulate;Covitol 700WD;Covitol 700;Copherol F 1250C;T-3376;Evicup;Vitapherol;Riken E Acetate α;D-Alpha-tocopheryl acetate;Onynex potassium;Onynex K;VEA Olio;1406-70-8;12741-00-3;26243-95-8
CAS No.: 58-95-7 Molecular Formula: C31H52O3
InChIKeys: InChIKey=ZAKOWWREFLAJOT-CEFNRUSXSA-N Molecular Weight: 472.743
Exact Mass: 472.74 EC Number: 231-710-0
UNII: A7E6112E4N DSSTox ID: DTXSID3021356|DTXSID1031096
HScode: 29362800 Categories: Vitamins and Minerals Medicines

PSA: 35.53000 XLogP3: 12.07
Appearance: D-alpha-tocopheryl acetate appears as odorless off-white crystals. Darkens at 401° F. (NTP, 1992) Density: 3 @ Temp: 21.34 °C”>0.9533 g/cm3 @ Temp: 21.34 °C
Melting Point: -27.5 °C Boiling Point: 224 °C @ Press: 0.3 Torr
Flash Point: 235.6±24.7 °C Refractive Index: 1.488
Water Solubility: <0.1 g/100 mL at 17 ºC Storage Conditions: 2-8ºC
Air and Water Reactions: This chemical may be sensitive to prolonged exposure to light and air. (NTP, 1992). Insoluble in water. Reactive Group: Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Reactivity Profile: An ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Classification of the substance or mixture

Hazardous to the aquatic environment, long-term (Chronic) – Category Chronic 4

GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word

Hazard statement(s)

H413 May cause long lasting harmful effects to aquatic life

Precautionary statement(s)
Prevention

P273 Avoid release to the environment.

Response

none

Storage

none

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.