L-Proline | CAS 147-85-3 | Amino Acid for Cosmetic Skincare - - PREMIUM INGREDIENT

L-Proline | CAS 147-85-3 | Amino Acid for Cosmetic Skincare, Pharmaceutical Intermediates and Dietary Supplements

Categories:

Amino Acids

CAS No:

147-85-3

3 / 1

Description

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

L-Proline
Synonym	Pyrrolidine-2-carboxylic acid, L-Prolin
CAS No.	147-85-3
EINECS No.	205-702-2
Molecular Formula	C₅H₉NO₂
Molecular Weight	115.13
Appearance	White crystalline powder
Assay	98.5% – 101.5%
Grade	Food Grade, Pharmaceutical Grade
Executive Standard	USP, EP, JP, AJI, FCC
Certifications	ISO9001, HALAL, KOSHER, Non-GMO

Product Overview

L-Proline, CAS 147-85-3, is a cyclic amino acid and a key structural component of collagen. It participates in the natural synthesis of collagen in the human body and helps maintain the health of connective tissues. Widely adopted as a nutritional ingredient, L-Proline is commonly incorporated into dietary supplements for joint and skin nutrition, functional food and beverage fortification, as well as clinical nutrition and pharmaceutical preparations. In cosmetic skincare formulations, it supports skin matrix structure and maintains skin elasticity. It appears as white crystalline powder. Our cosmetic, food and pharma grade L-Proline conforms to AJI, USP, EP and CP.

Character

L-Proline appears as white crystalline powder and is soluble in water. It maintains stable physical and chemical properties under cool, dry and sealed storage conditions. Produced by microbial fermentation, L-Proline delivers high purity, low impurities and consistent batch quality. Thanks to its unique cyclic molecular structure, it serves as an essential building block for collagen formation and supports normal connective tissue metabolism.

Main Functions

1.Collagen Structure Support — acts as an essential building block for collagen biosynthesis

2.Joint & Connective Tissue Health — supports normal function of connective tissues

3.Skin Nutrition Support — contributes to nutritional support for skin structure

4.Amino Acid Supplementation — supplies amino acid for compound nutritional blends

5.Nutritional Fortification — used for fortifying dietary supplements and functional food

6.Clinical Nutrition Formulation — suitable for compound amino acid clinical nutrition formulas

Applications

1. Cosmetic: Functional ingredient to support skin matrix and elasticity for skincare products

2.Dietary Supplements — collagen related formulations, joint nutritional supplements, amino acid capsules

3.Functional Food & Beverage — nutritional beauty food, fortified drinks and functional food products

4.Clinical Nutrition — compound amino acid preparations and clinical nutrition formulations

5.Pharmaceutical Preparations — raw material for amino acid based pharmaceutical intermediates

Packaging & Storage

Packaging: 25kg kraft paper bag with inner PE bag, customized packaging available

Storage: Keep in cool, dry and ventilated place, tightly sealed, avoid direct sunlight and high temperature

Shelf life: 24 months under proper storage conditions

Product Name:	L-Proline	Other Name:	L-Proline;Proline,L-;Proline;L-(-)-Proline;2-Pyrrolidinecarboxylic acid,(S)-;(S)-(-)-Proline;2-Pyrrolidinecarboxylic acid;(-)-Proline;(S)-Proline;(S)-2-Pyrrolidinecarboxylic acid;(-)-2-Pyrrolidinecarboxylic acid;L-Pyrrolidine-2-carboxylic acid;L-α-Pyrrolidinecarboxylic acid;Carboxypyrrolidine;NSC 46703;(S)-2-Carboxypyrrolidine;(2S)-Pyrrolidine-2-carboxylic acid;21: PN: WO2021055880 SEQID: 22 claimed protein;7005-20-1;95650-41-2;1150316-19-0
CAS No.:	147-85-3	Molecular Formula:	C5H9NO2
InChIKeys:	InChIKey=ONIBWKKTOPOVIA-BYPYZUCNSA-N	Molecular Weight:	115.13000
Exact Mass:	115.13	EC Number:	205-702-2
HScode:	2933990090	Categories:	Amino Acids and Derivatives

PSA:	49.33000	XLogP3:	-2.5
Appearance:	Solid	Density:	3 @ Temp: 45.00 °C”>1.4063 g/cm3 @ Temp: 45.00 °C
Melting Point:	220-222 °C (decomp)	Boiling Point:	252.2ºC at 760 mmHg
Flash Point:	106.3ºC	Refractive Index:	-85 ° (C=4, H2O)
Water Solubility:	H2O: soluble	Storage Conditions:	Store at RT.
Vapor Pressure:	0.00615mmHg at 25°C	Specific rotation:	SPECIFIC OPTICAL ROTATION: -80.9 DEG @ 20 °C/D (WATER, 1%); SADTLER REF NUMBER: 1905 (IR, PRISM)
Odor:	Odorless	Taste:	Sweet

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids.