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| Product Name: | L-Histidine | Other Name: | L-Histidine;Histidine,L-;Histidine;1H-Imidazole-4-propanoic acid,α-amino-,(S)-;(S)-4-(2-Amino-2-carboxyethyl)imidazole;Glyoxaline-5-alanine;L-(-)-Histidine;(S)-Histidine;(S)-α-Amino-1H-imidazole-4-propanoic acid;1H-Imidazole-4-alanine,(S)-;L-Alanine,3-(1H-imidazol-4-yl)-;NSC 137773;(2S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid;8: PN: EP2878667 TABLE: 5 claimed sequence;(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid;(2S)-2-Azaniumyl-3-(1H-imidazol-5-yl)propanoate;(2S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid;124: PN: WO2020191245 SEQID: 252 claimed protein;103: PN: WO2021061872 SEQID: 103 claimed protein;150-35-6;7006-35-1;35479-49-3;35558-59-9;45955-20-2;54166-13-1;736075-03-9;155304-24-8 |
| CAS No.: | 71-00-1 | Molecular Formula: | C6H9N3O2 |
| InChIKeys: | InChIKey=HNDVDQJCIGZPNO-YFKPBYRVSA-N | Molecular Weight: | 155.15 |
| Exact Mass: | 155.15 | BRN: | 4673585 |
| EC Number: | 200-745-3 | UNII: | 4QD397987E |
| DSSTox ID: | DTXSID9023126 | NCI Thesaurus Code: | C29597 |
| Color/Form: | Needles or plates|COLORLESS | HScode: | 29332990 |
| Categories: | Amino Acids and Derivatives |
| PSA: | 92 | XLogP3: | -3.2 |
| Appearance: | White to off-white or pale yellow powder | Density: | 1.3092 (rough estimate) |
| Melting Point: | 287 °C (decomp) | Boiling Point: | 278.95°C (rough estimate) |
| Flash Point: | 282ºC | Refractive Index: | 1.731 |
| Water Solubility: | H2O: 41.6 g/L (25 ºC) | Storage Conditions: | Store at RT. |
| Toxicity: | 5110 mg/kg”>LD50 orally in Rabbit: > 5110 mg/kg | Specific rotation: | 12.4 º (c=11,6N HCl) |
| Taste: | Sweet | PKA: | 2.76(at 0 °C) |
| Dissociation Constants: | 2.76 (at 0 °C)|pK1’= 1.78; pK2’= 5.97; pK3’= 8.97|pKa = 2.76 @ 0 °C | Collision Cross Section: | 131.9 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|132.41 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|131.47 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|127 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|131.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|132.1 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|134.6 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|134.8 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|128.1 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|128.5 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|130.01 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|132.74 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|135.48 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|128.9 Ų [M-H]- |
| Experimental Properties: | Softens @ 277 °C|Rhombic crystals (also forms a monohydrate) /L-histidine monohydrochloride/; rhombic crystals, isomorphous with the mono-HCl /L-histidine dihydrochloride/|UV: 11479 (Sadtler Research Laboratories Spectral Collection) /dl-Histidine/ |
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word |
No signal word |
| Hazard statement(s) |
none |
| Precautionary statement(s) | |
| Prevention |
none |
| Response |
none |
| Storage |
none |
| Disposal |
none |
Other hazards which do not result in classification
no data available
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.