L-Arginine Hydrochloride | CAS 1119-34-2 | Amino Acid for Sports Nutrition - - PREMIUM INGREDIENT

L-Arginine Hydrochloride (L-Arginine Hcl) | CAS 1119-34-2 | Amino Acid for Sports Nutrition and Pharmaceutical

Categories:

Amino Acids

CAS No:

1119-34-2

4 / 1

Description

Certificates

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

Item	Details
Product Name	L-Arginine Hydrochloride
Synonyms	L-Arginine HCl, L-Arginine Monohydrochloride
CAS Number	1119-34-2
Molecular Formula	C₆H₁₄N₄O₂·HCl
Molecular Weight	210.66
Appearance	White crystals or crystalline powder
Available Grades	Food Grade, Pharma Grade
Purity	≥98.5%
Solubility	Freely soluble in water (~860 g/L at 25°C)
pH (aqueous solution)	~5.7 (slightly acidic)
Executive Standards	USP, CP, BP, EP, JP, AJI
Certifications	ISO9001, ISO22000, HALAL, KOSHER, HACCP

Product Overview

L-Arginine Hydrochloride (CAS 1119-34-2) is the hydrochloride salt form of L-arginine, a conditionally essential amino acid and nitric oxide (NO) precursor. Compared with free base L-arginine, it offers dramatically higher water solubility and a near-physiological pH (~5.7), making it the preferred form for liquid formulations, injections and clinical nutrition products.

We supply food grade and pharma grade. Food grade is widely used in dietary supplements, sports nutrition powders and instant dissolving drink mixes. Pharma grade is applied in amino acid injections, infusion solutions and oral liquid preparations. It is also used as a pH adjuster and stabilizer in cosmetic and pharmaceutical formulations. Compliant with USP, CP, BP, EP, JP and AJI standards, certified by ISO9001, ISO22000, HALAL, KOSHER and HACCP for global export.

Product Characteristics

1.Exceptionally high water solubility Freely soluble in water (~860 g/L at 25°C), far exceeding free base form — ideal for instant dissolving powders, beverages and liquid formulations.

2.Near-physiological pH (~5.7) Slightly acidic solution provides good compatibility with human blood, making it suitable for intravenous and oral liquid preparations.

3.Hydrochloride salt form of L-arginine Dissociates in vivo to release bioavailable L-arginine as NO precursor, same biological function as free base.

4.Stable crystalline powder White crystals or crystalline powder, stable in dry state, suitable for bulk storage and industrial production.

5.Dual-grade supply Food grade for nutraceutical and beverage applications; pharma grade for injection and clinical formulations.

Main Functions

1.Nitric oxide (NO) biosynthesis support Releases L-arginine as substrate for NO production, supporting vasodilation and healthy blood circulation.

2.Cardiovascular & circulatory nutrition Supports vascular health and normal blood flow through the L-arginine-NO pathway.

3.High-solubility amino acid fortification Enables rapid dissolution in liquid supplement drinks and reconstitutable powder products.

4.Clinical nutrition & infusion raw material Used in amino acid infusions and parenteral nutrition formulations for medical nutrition support.

5.pH buffer & formulation stabilizer Serves as a buffering and stabilizing agent in pharmaceutical and cosmetic formulations.

Main Applications

1. Dietary Supplements & Sports Nutrition

Widely used in pre-workout powders, amino acid drink mixes, capsule and tablet supplements targeting NO support, muscle pump, recovery and men’s health nutrition. Its high solubility makes it ideal for instant dissolving sports drinks and effervescent formulations.

2. Pharmaceutical Industry

Key raw material for amino acid injections, infusion solutions and oral liquid preparations. The hydrochloride form’s high solubility and blood-compatible pH (~5.7) make it the standard choice for intravenous arginine therapy and clinical nutrition products.

3. Functional Beverages & Instant Powders

Added to functional drink mixes and reconstitutable powder products requiring rapid and complete dissolution in water.

4. Cosmetic & Personal Care

Used as a pH adjuster and humectant/stabilizing ingredient in skincare formulations.

Packaging & Storage

Item	Specification
Packaging	25kg fiber drum with waterproof inner bag
Storage Condition	Store in cool, dry, ventilated warehouse, avoid direct sunlight and high temperature
Sealing Requirement	Keep tightly sealed to prevent moisture absorption and caking
Shelf Life	24 months under standard storage conditions

L-Arginine Base vs L-Arginine HCl

Parameter	L-Arginine (Free Base)	L-Arginine HCl
CAS Number	74-79-3	1119-34-2
Molecular Formula	C₆H₁₄N₄O₂	C₆H₁₄N₄O₂·HCl
Molecular Weight	174.20	210.66
Water Solubility	~148 g/L (sparingly soluble)	~860 g/L (freely soluble)
pH (aqueous)	10.5–12.0 (alkaline)	~5.7 (slightly acidic)
Chloride Content	Chloride-free	Contains chloride ions
Best For	Solid supplements, capsules, chloride-free formulas, food additives	Injections, infusions, liquid drinks, instant powders, clinical nutrition
Typical Grades	Food Grade, Pharma Grade	Food Grade, Pharma Grade
Key Selling Point	Chloride-free, high active arginine content	Ultra-high solubility, blood-compatible pH

CERTIFICATE OF ANALYSIS (SAMPLE)

Product: L-Arginine Monohydrochloride (L-Arginine HCL) CAS N o : (1119-34-2) Quantity: 1000KG Lot No: Date: APR 16, 2023
Item	Specification	Result
Appearance	White or almost white crystal line powder or colorless crystals	conform
Identification	Infrared Absorptioon	conform
Specific rotation [α] D 20	+21.4 to +23.6°	+22.5°
Loss on Drying	Not more than 0.2%	0. 12%
Residue on ignition(s ulfated)	Not more than 0. 1%	0.07%
Sulfate ( SO 4 )	Not more than 0.03%	<0.03 %
Chloride(Cl)	16.5 to 17. 1%	16.7%
Heavy metals(Pb)	Not more than 20 ppm	<20 ppm
Chromatographic puri ty	Not more than 0.5% of an individual impurity is found ; Not more than 2.0% of total impurities is found .	Conforms
Assay	98.5 to 101.0%	99.6%

Conclusion : Agree with the specification of USP 41.

Product Name:	L-Arginine, monohydrochloride	Other Name:	L-Arginine,hydrochloride (1:1);Arginine,monohydrochloride,L-;L-Arginine,monohydrochloride;Argivene;R-Gene;Arginine hydrochloride;Arginine monohydrochloride;L-Arginine hydrochloride;Arginine monochloride;Argamine;Detoxargin;Levargin;Minophagen A;NSC 203450;NSC 7914;L-(+)-Arginine monohydrochloride;Tivortin;L-(+)-Arginine hydrochloride
CAS No.:	1119-34-2	Molecular Formula:	C6H14N4O2.ClH
InChIKeys:	InChIKey=KWTQSFXGGICVPE-WCCKRBBISA-N	Molecular Weight:	210.66
Exact Mass:	210.088348	BRN:	3631658
EC Number:	214-275-1	HScode:	29252000
Categories:	Amino Acids and Derivatives

PSA:	128	XLogP3:	1.35480
Appearance:	white powder	Density:	1.42
Melting Point:	222 °C	Boiling Point:	409.1ºC at 760 mmHg
Flash Point:	201.2ºC	Water Solubility:	soluble in water. Slightly soluble in hot alcohol.H2O: 100 mg/mL
Storage Conditions:	2-8°C	Toxicity:	Peritoneal-rat LD50: 3793mg/kg; oral-rat LD50: 12000 mg/kg
Flammability characteristics:	Flammable; burning produces toxic nitrogen oxides and hydrogen chloride fumes	Specific rotation:	22 º (c=8,6N HCl)

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.