L-Citrulline | CAS 372-75-8 | Amino Acid for Sports Nutrition - - PREMIUM INGREDIENT

L-Citrulline | CAS 372-75-8 | Amino Acid for Sports Nutrition, Food and Health Ingredients

Categories:

Amino Acids

CAS No:

372-75-8

3 / 1

Description

Certificates

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

Item	Details
Product Name	L-Citrulline
Synonyms	L-Cit, (S)-2-Amino-5-ureidopentanoic acid
CAS Number	372-75-8
Molecular Formula	C₆H₁₃N₃O₃
Molecular Weight	175.19
Appearance	White crystalline powder
Available Grades	Food Grade, Pharma Grade
Purity	≥98.5%
Solubility	Soluble in water
Executive Standards	USP, EP, CP, AJI, FCC
Certifications	ISO9001, ISO22000, HALAL, KOSHER, HACCP

Product Overview

L-Citrulline (CAS 372-75-8) is a conditionally non-essential amino acid and widely applied in sports nutrition and healthy food formulas. It plays a vital role in the human nitric oxide cycle, effectively promoting blood circulation, improving oxygen and nutrient delivery to muscle tissues, delaying exercise-induced fatigue, and enhancing physical endurance and post-workout muscle recovery. For this reason, it is a core raw material for various sports dietary supplements, bodybuilding formulas, and functional nutritional products. In functional food industry, L-Citrulline is commonly used for daily cardiovascular health support and body metabolism regulation. It also has minor applications in special medical nutrition and pharmaceutical auxiliary formulations for amino acid metabolic adjustment.

Product Characteristics

1.Efficient precursor to L-arginine and NO L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic first-pass metabolism — delivering more sustained arginine and NO elevation compared with direct arginine intake.

2.White crystalline powder, good water solubility Suitable for reconstitutable powders, sports drinks and capsule formulations.

3.Non-essential amino acid in urea cycle Participates in ammonia detoxification and nitrogen metabolism in the body.

4.Food grade and pharma grade supply Food grade for supplement and beverage markets; pharma grade for cardiovascular and clinical nutrition products.

5.Popular sports nutrition ingredient One of the fastest-growing amino acid ingredients in pre-workout and endurance supplement categories globally.

Main Functions

1.Sustained nitric oxide support Converts to L-arginine in vivo, supporting NO-mediated vasodilation and healthy blood flow with longer-lasting effect than direct arginine.

2.Sports performance & endurance support Used in pre-workout and endurance formulations to support oxygen delivery, muscle pump and reduced fatigue during exercise.

3.Muscle recovery & nitrogen metabolism Supports post-exercise recovery and urea cycle function, helping clear metabolic waste products.

4.Cardiovascular & circulatory nutrition Supports healthy blood vessel function and circulation through the citrulline-arginine-NO pathway.

5.Dietary supplement fortification Common ingredient in men’s health, wellness and daily amino acid supplement blends.

Main Applications

1. Sports Nutrition & Pre-Workout

L-Citrulline is one of the most popular ingredients in pre-workout powders, endurance drinks and recovery formulations. It is widely used in citrulline-only, citrulline-malate and multi-amino acid sports nutrition blends targeting muscle pump, endurance and post-workout recovery.

2. Dietary Supplements & Men’s Health

Added to capsule, tablet and powder supplement products targeting circulatory support, men’s health nutrition and overall wellness. Often combined with L-arginine, antioxidants or other amino acids in NO-boosting supplement formulas.

3. Functional Beverages & Food Fortification

Used in functional drinks, energy beverages and fortified food products to support amino acid nutrition and circulatory health positioning.

4. Pharmaceutical & Clinical Nutrition

Pharma grade L-Citrulline is used in cardiovascular nutrition products, clinical nutrition formulations and as a raw material for related pharmaceutical preparations.

Packaging & Storage

Item	Specification
Packaging	25kg fiber drum with waterproof inner bag
Storage Condition	Store in cool, dry, ventilated warehouse, avoid direct sunlight and high temperature
Sealing Requirement	Keep tightly sealed to prevent moisture absorption and caking
Shelf Life	24 months under standard storage conditions

CERTIFICATE OF ANALISIS (SAMPLE)

Product: L-Citrulline CAS No: (372-75-8) Quantity: 25KGS X 40 Lot No: Date:
Item	Specification	Result	Test Methods
Appearance	White crystals or crystalline powder	Conforms	Visual
Specific rotation [α]D20	+24.5 to +26.8°	+25.9°	AJI TEST 1
Identification	As Per AJI92	Conforms	Chromogenic Reaction
State of solution(Transmittance)	Not less than 98.0%	99. 1%	AJI TEST 2
Chloride(CL)	Not more than 0.020%	<0.020%	AJI TEST 3
Ammonium(NH4)	Not more than 0.02%	< 0.02%	AJI TEST 4
Sulfate(SO4)	Not more than 0.020%	< 0.020%	AJI TEST 5
Iron(Fe)	Not more than 10ppm	<10ppm	AJI TEST 6
Heavy metals(Pb)	Not more than 10ppm	<10ppm	AJI TEST 7
Lead	Not more than 3ppm	<3ppm	AFS
Arsenic( AS2O3)	Not more than 1ppm	<1ppm	AJI TEST 8
Cadmium	Not more than 1ppm	<1ppm	AFS
Mercury(Hg)	Not more than 0. 1ppm	<0. 1ppm	AAS
Loss on Drying	Not more than 0.30%	0.25%	AJI TEST 11
Residue on ignition(sulfated)	Not more than 0. 10%	0.04%	AJI TEST 13
Assay	98.5 to 101.0%	99.3%	AJI TEST 15
pH	5.0 to 7.0	6. 1	AJI TEST 33

Conclusion: Agree with the specification of AJI92.

Product Name:	Citrulline	Other Name:	L-Ornithine,N5-(aminocarbonyl)-;Ornithine,N5-carbamoyl-,L-;N5-(Aminocarbonyl)-L-ornithine;α-Amino-δ-ureidovaleric acid;Nδ-Carbamylornithine;δ-Ureidonorvaline;Citrulline;N5-Carbamoyl-L-ornithine;Cit;L-Citrulline;NSC 27425;L-(+)-Citrulline
CAS No.:	372-75-8	Molecular Formula:	C6H13N3O3
InChIKeys:	InChIKey=RHGKLRLOHDJJDR-BYPYZUCNSA-N	Molecular Weight:	175.19
Exact Mass:	175.19	BRN:	6055157
EC Number:	206-759-6	UNII:	29VT07BGDA
NCI Thesaurus Code:	C53406	HScode:	29241900
Categories:	Amino Acids and Derivatives

PSA:	118	XLogP3:	-3.19
Appearance:	White Crystals or Crystalline Powder	Density:	1.3±0.1 g/cm3
Melting Point:	235.5 °C	Boiling Point:	306.48°C (rough estimate)
Flash Point:	187.7±27.9 °C	Refractive Index:	1.531
Water Solubility:	H2O: 200 g/L (20 ºC)	Storage Conditions:	Store at 0-5°C
Specific rotation:	25.5 º (c=8, 6N HCl)	PKA:	2.43(at 25 °C)
Dissociation Constants:	2.43 (at 25 °C)	Collision Cross Section:	138 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]\|139.51 Å² [M-H]- [CCS Type: DT, Method: stepped-field]\|132 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]\|137.7 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|139.4 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|135.4 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|135.5 Å² [M-H]-

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation
Prevention	P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
Response	P302+P352 IF ON SKIN: Wash with plenty of water/… P321 Specific treatment (see … on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.