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Basic Information

 

L-Threonine
Synonyms L-2-Amino-3-hydroxybutanoic acid
CAS Number 72-19-5
Molecular Formula C₄H₉NO₃
Molecular Weight 119.12
Appearance

white to pale yellowish crystalling powder (feed grade)

white crystalline powder (food grade)

Available Grades Feed Grade, Food Grade
Purity ≥98.5%
Solubility Freely soluble in water, practically insoluble in ethanol
Executive Standards USP, EP, CP, AJI, FCC
Certifications ISO9001, ISO22000, HALAL, KOSHER, HACCP, FAMI-QS

 

Product Overview

L-Threonine (CAS 72-19-5) is an indispensable essential amino acid for human and animal growth, which cannot be synthesized independently in the body. As the third limiting amino acid for corn-soybean meal feed, it is the core and high-demand additive in the global animal feed industry. It effectively balances dietary amino acid ratios, improves feed conversion rate, and promotes healthy growth of livestock, poultry and aquatic animals. In addition to its dominant application in feed fortification, L-Threonine is also used for functional food nutrition enhancement, human health dietary supplements, and clinical pharmaceutical amino acid preparations.

Industrial high-purity L-Threonine is produced by advanced microbial fermentation technology, using corn raw materials through liquid deep fermentation, filtration, concentration, crystallization and multi-stage purification procedures, featuring stable batch quality and large-scale supply capacity.

 

Character

L-Threonine is a white, uniform and free-flowing crystalline powder with no peculiar odor and mild sweet taste. It has good water solubility and stable physical and chemical properties under normal temperature and dry storage conditions. The product features high purity, low impurity content, excellent fluidity and uniform particle size, which is convenient for mixing and processing in feed, food and pharmaceutical production. It maintains excellent structural stability and is not easy to deteriorate or agglomerate during long-term storage.

 

Main Functions

1.Promote livestock and poultry growth performance (Core Function) Supplementing L-Threonine significantly improves the daily weight gain and growth uniformity of pigs, chickens, ducks and other livestock and poultry, shortens the breeding cycle, and improves breeding efficiency.

2.Improve feed conversion rate It optimizes nutrient metabolism and protein deposition in animals, reduces feed waste, and greatly improves the economic benefits of feed formula and breeding production.

3.Maintain animal intestinal health As a key raw material for intestinal mucosal synthesis, it enhances intestinal barrier function, reduces diarrhea rate of young animals, and improves animal survival rate and health status.

4.Improve animal immunity and stress resistance Moderate threonine supplementation regulates animal immune system metabolism, enhances body resistance to external stress, and reduces disease incidence during high-density breeding.

5.Food nutrition balancing supplementation In food industry, it supplements human essential amino acids, balances dietary nutrition structure, and improves the nutritional value of processed foods.

6.Basic pharmaceutical and biochemical nutrition support It is used in basic amino acid formula preparations to assist in maintaining normal human metabolic balance, with limited and auxiliary application scope.

 

Main Applications

 

1. Animal Feed Industry (Core & Largest Application)

Feed Grade L-Threonine is the dominant application scenario of the product, widely used in compound feed and premix for pigs, broilers, laying hens, ducks and other livestock and poultry.

In pig breeding, it is specially used for piglet feed and growing-finishing pig feed to effectively reduce piglet diarrhea, promote skeletal and muscle growth, and improve feed remuneration. In poultry breeding, it optimizes poultry growth and feather development, reduces malnutrition and growth retardation, and improves flock uniformity.

It is a necessary conventional additive in modern low-protein feed formulas, helping feed factories reduce raw material costs while ensuring breeding effects, and is widely recognized and adopted in global large-scale breeding bases.

 

2. Food Industry 

Food Grade L-Threonine is applied in nutritional fortified foods, grain products and daily nutritional formula foods. It supplements essential amino acids required by human body, optimizes food nutritional structure, and improves the comprehensive nutritional value of finished food products with small dosage and targeted fortification characteristics.

3. Pharmaceutical & Biochemical Industry

L-Threonine is occasionally used in compound amino acid preparations and basic biochemical raw material production, providing auxiliary nutritional support for human metabolic regulation, with narrow application range and low market demand.

 

Packaging & Storage

 

Item Specification
Packaging 25kg fiber drum or woven bag with waterproof inner plastic bag
Storage Condition Store in cool, dry and ventilated warehouse, keep away from high temperature, humidity and direct sunlight
Sealing Requirement Keep tightly sealed to prevent moisture absorption and agglomeration
Shelf Life 24 months under standard storage conditions
 

CERTIFICATE OF ANALYSIS (SAMPLE)

FOR L-THREONINE 98.5% FEED GRADE

 

Chemical formula: C4H9NO3

Molecular Weight 119.12

Percent Nitrogen 11.50%

Description Yellowish-white,crystal powder

Solubility in H2O 9.76 g/100 g water at 20ºC

Purity(on a dry matter basis)98.5% (Min) Bulk Density kg/L 0.6 – 0.7

INVOICE NO.:                                                       QUANTITY.:22MT

BATCH NO:19021323                                    MAF DATE:FEB.13,2019                                     EXPIRY DATE. :FEB.12,2022

ITEM

STANDARD

TEST RESULT

TEST METHOD

Purity(on a dry matter basis)

≥98.5%

99.2

GBT21979-2008

RESIDUE ON IGNITION %

≤0.5%

0.10

GB/T6438

LOSS ON DRYING

≤1.0%

0.02

GB/T 6435

SPECIFIC ROTATION [α]D20℃

-260   – -290

-28.05

GBT21979-2008

HEAVY METALS ( Pb)

≤20PPM

Conform

GB/T 13080

ARSENIC (As)

≤2PPM

Conform

GB/T 13079

 

Country of Origin: China Packing: 25kg per bag

 

 

 

 

 

 

CERTIFICATE OF ANALYSIS

 

Product Name: L-Threonine

Batch No.:B240709-3

Quantity:500kg

Reference standard: USP40

Packing: 25kg/Bag

Producing date: 2024.07.09

Sampling date:2024.07.10

Send out date:2024.07.10

Expiry date:2026.07.08

 

Items

Specification

Result

Description

White crystals or crystalline powder

Conforms

Assay,%

98.5~ 101.5

99.3

Identification

Infrared Absorption

Conforms

Specific rotation

-26.7 °~-29.1 °

-28.2 °

PH value

5.0~6.5

5.70

Loss on drying,%

≤0.2

0.10

Residue on ignition ,%

≤0.4

0.07

Chloride, %

≤0.05

<0.05

Sulfate ,%

≤0.03

<0.03

Iron, ppm

≤30

<30

Heavy metals, ppm

≤15

<15

Related Compounds

Meets the requirements

Conforms

Conclusion: The goods conforms to reference standard of USP40.

 

Inspectors:DingChunhong                      Checker: Zhulinlin                    Director:Wang shuli

Product Name: L-Threonine Other Name: L-Threonine;Threonine,L-;Butanoic acid,2-amino-3-hydroxy-,[R-(R*,S*)]-;Threonine;Threonin;[R-(R*,S*)]-2-Amino-3-hydroxybutanoic acid;(S)-Threonine;L-(-)-Threonine;2-Amino-3-hydroxybutyric acid;NSC 16589;NSC 46701;48: PN: WO2004076659 FIGURE: 7 claimed protein;46: PN: WO2005016244 PAGE: 70 claimed protein;49: PN: WO2005016244 PAGE: 70 claimed protein;3046: PN: WO2004111636 SEQID: 516 unclaimed protein;2: PN: US20090069547 PAGE: 10 claimed protein;17: PN: WO2011044089 SEQID: 18 claimed protein;4: PN: WO2012076822 PAGE: 51 claimed sequence;(2S,3R)-2-Amino-3-hydroxybutanoic acid;13095-55-1;25275-17-6;36676-50-3;154605-64-8;154605-68-2;1043597-96-1;1370710-06-7;1644578-86-8
CAS No.: 72-19-5 Molecular Formula: C4H9NO3
InChIKeys: InChIKey=AYFVYJQAPQTCCC-GBXIJSLDSA-N Molecular Weight: 119.11900
Exact Mass: 119.12 EC Number: 200-774-1
UNII: 2ZD004190S NSC Number: 760118
DSSTox ID: DTXSID2046412 NCI Thesaurus Code: C29602
Color/Form: Colorless crystals|Crystals HScode: 29225000
Categories: Amino Acids and Derivatives

PSA: 83.55000 XLogP3: -2.9
Appearance: Solid Density: 1.307g/cm3
Melting Point: 256 °C (decomp) Boiling Point: 345.803ºC at 760 mmHg
Flash Point: 162.936ºC Refractive Index: 1.507
Water Solubility: H2O: 97.0 mg/mL Storage Conditions: Store at RT.
Vapor Pressure: 1.32X10-8 mm Hg at 25 deg C (est) PKA: 5.6None
Henrys Law Constant: Henry’s Law constant = 7.24X10-14 atm-cu m/mol at 25 °C (est) Dissociation Constants: 5.60|pKa1′ = 2.63 (SRC: carboxylic acid); pKa2′ = 10.43 (SRC: amine)
Collision Cross Section: 141.36 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|122 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|126.7 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|120.2 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|129.2 Ų [M-H]- Experimental Properties: Orthorhombic crystals, decomposes at 229-230 °C /Threonine, DL-form hemihydrate/|UV: 1-34 (Organic Electronic Spectral Data, Phillips et al, John Wiley & Sons, New York) /Threonine (DL)/

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.