L-Leucine | CAS 61-90-5 | Amino Acid for BCAA, Sports Nutrition - - PREMIUM INGREDIENT

L-Leucine | CAS 61-90-5 | Amino Acid for BCAA, Sports Nutrition, Food and Health Ingredients

Categories:

Amino Acids

CAS No:

61-90-5

3 / 1

Description

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

Item	Details
Product Name	L-Leucine
Synonym	(S)-2-Amino-4-methylpentanoic acid, L-Leu
CAS No.	61-90-5
EINECS No.	200-522-0
Molecular Formula	C₆H₁₃NO₂
Molecular Weight	131.17
Appearance	White crystalline powder
Assay	98.5% – 101.5%
Grade	Food Grade, Pharmaceutical Grade, Supplement Grade
Executive Standard	USP, EP, JP, AJI
Certifications	ISO9001, HALAL, KOSHER, Non-GMO

Product Overview

L-Leucine is an essential branched-chain amino acid (BCAA) that cannot be synthesized by the human body. It is well-known for supporting muscle protein synthesis and maintaining muscle tissue metabolism. Widely applied in sports nutrition supplements, functional food fortification, clinical nutrition formulas, and pharmaceutical amino acid preparations, L-Leucine is one of the most high-value nutritional amino acids for fitness and healthy metabolism support.

Character

L-Leucine appears as fine white crystalline powder with stable physical and chemical properties under normal storage conditions. It is soluble in water and features high purity, low impurity content, and stable batch consistency. Produced by advanced microbial fermentation technology, this essential BCAA ensures safe and reliable quality for food, supplement, and pharmaceutical-grade applications. It plays a unique regulatory role in human protein metabolism compared with other amino acids.

Main Functions

1.Muscle Protein Synthesis Support — stimulates natural muscle protein synthesis and supports muscle maintenance

2.Sports Nutrition & Recovery — helps relieve exercise fatigue and accelerate physical recovery

3.Metabolism Regulation — participates in body energy metabolism and nitrogen balance regulation

4.Essential Amino Acid Supplementation — complements daily nutritional deficiency of branched-chain amino acids

5.Functional Food Fortification — enhances nutritional value of health food and protein formulas

6.Clinical Nutrition Support — applied in compound amino acid solutions for physical rehabilitation nutrition

Applications

1.Sports & Dietary Supplements — fitness formulas, BCAA blends, muscle support tablets and powder supplements (core largest application)

2.Functional Food & Beverage — high-protein food, nutritional drinks, meal replacement and fortified health food

3.Clinical Nutrition Formulation — rehabilitation nutrition, compound amino acid infusion preparations

4.Pharmaceutical Raw Materials — used in biochemical reagents and pharmaceutical intermediate manufacturing

Packaging & Storage

Packaging: 25kg kraft paper bag with inner PE bag, customized packaging available

Storage: Store in cool, dry, ventilated warehouse, keep tightly sealed, avoid high temperature, humidity and direct sunlight

Shelf Life: 24 months under proper storage conditions

CERTIFICATE OF ANALYSIS (SAMPLE)

Product Name: L-Leucine	Quantity:1000kg	Batch No:
Producing date: 2022.09.20	Date of Analysis: 2022.09.20	Expiry date: 2024.09.19
Reference standard: USP36	Package: 25kg Paper Drum	CAS No.: 61-90-5
Item	Specifications	Results
Specific rotation [a]D20°	+14.9o ~ +17.3o	+15.6o
Transmittance	≥98.0%	98.9%
Loss on drying	≤0.20%	0.08%
Residue on ignition	≤0. 10%	0.07%
mesh	100% Pass 60mesh	Conformed
Chloride (Cl)	≤0.04%	0.03%
Sulfate	≤0.03%	0.02%
Iron（Fe）	≤0.003%	0.0005%
Heavy metals（Pb）	≤0.0015%	0.00006%
Assay	98.5%～101.5%	99.8%
Conclusion: This product complies with USP36 standard.

Product Name:	L-Leucine	Other Name:	L-Leucine;Leucine,L-;Leucine;Pentanoic acid,2-amino-4-methyl-,(S)-;Leu;(S)-2-Amino-4-methylvaleric acid;(S)-(+)-Leucine;(S)-2-Amino-4-methylpentanoic acid;(S)-Leucine;L-α-Aminoisocaproic acid;L-(+)-Leucine;L-Norvaline,4-methyl-;NSC 46709;(2S)-2-Amino-4-methylpentanoic acid;L-2-Amino-4-methylpentanoic acid;(2S)-2-Amino-4-methylpentanoic acid;1: PN: WO2020097235 SEQID: 238 claimed sequence;17: PN: WO2021055880 SEQID: 18 claimed protein;7005-03-0
CAS No.:	61-90-5	Molecular Formula:	C6H13NO2
InChIKeys:	InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N	Molecular Weight:	131.17300
Exact Mass:	131.17	EC Number:	200-522-0
UNII:	GMW67QNF9C	NSC Number:	760100
DSSTox ID:	DTXSID9023203	NCI Thesaurus Code:	C29599
Color/Form:	White glistening hexagonal plates from aqueous alcohol\|White crystals	HScode:	29224995
Categories:	Amino Acids and Derivatives

PSA:	63.32000	XLogP3:	-1.5
Appearance:	Solid	Density:	3″>1.14 g/cm3
Melting Point:	293 °C	Boiling Point:	122-134 °C @ Press: 2-3 Torr
Flash Point:	90.3ºC	Refractive Index:	1.463
Water Solubility:	H2O: 22.4 g/L (20 C)	Storage Conditions:	Store at RT.
Vapor Pressure:	<1 hPa (20 °C)	Specific rotation:	Specific optical rotation: -10.8 at 25 °C/D (c = 2.2); +15.1 deg at 26 °C/D in 6N HCl (38 mols HCl per mol leucine); +7.6 deg at 20 °C/D in 3N NaOH (30 mols NaOH per mol leucine). Molecular rotation: +21.0 deg at /D (5NHCl); +29.5 deg /D (glacial acetic acid)
PKA:	2.35(at 13 °C)	Henrys Law Constant:	Henry’s Law constant = 3.49X10-9 atm-cu m/mol at 25 °C (est)
Dissociation Constants:	2.35 (at 13 °C)\|pKa = 2.35\|pKa1 = 2.36 (carboxylic acid); pKa2 = 9.63 (amine) (est)	Collision Cross Section:	135.16 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]\|138.71 Å² [M-H]- [CCS Type: DT, Method: stepped-field]\|128 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]\|134.8 Å² [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|130.6 Å² [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|132.51 Å² [M-H]- [CCS Type: DT, Method: stepped-field]\|135.56 Å² [M+H]+ [CCS Type: DT, Method: stepped-field]\|131.8 Å² [M-H]-
Experimental Properties:	Crystals. Freely soluble in water. /Leucine hydrochloride/\|Hydroxyl radical reaction rate constant = 4.23X10-11 cu cm/molec-sec at 25 °C (est)

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.