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| Product Name: | L-Leucine | Other Name: | L-Leucine;Leucine,L-;Leucine;Pentanoic acid,2-amino-4-methyl-,(S)-;Leu;(S)-2-Amino-4-methylvaleric acid;(S)-(+)-Leucine;(S)-2-Amino-4-methylpentanoic acid;(S)-Leucine;L-α-Aminoisocaproic acid;L-(+)-Leucine;L-Norvaline,4-methyl-;NSC 46709;(2S)-2-Amino-4-methylpentanoic acid;L-2-Amino-4-methylpentanoic acid;(2S)-2-Amino-4-methylpentanoic acid;1: PN: WO2020097235 SEQID: 238 claimed sequence;17: PN: WO2021055880 SEQID: 18 claimed protein;7005-03-0 |
| CAS No.: | 61-90-5 | Molecular Formula: | C6H13NO2 |
| InChIKeys: | InChIKey=ROHFNLRQFUQHCH-YFKPBYRVSA-N | Molecular Weight: | 131.17300 |
| Exact Mass: | 131.17 | EC Number: | 200-522-0 |
| UNII: | GMW67QNF9C | NSC Number: | 760100 |
| DSSTox ID: | DTXSID9023203 | NCI Thesaurus Code: | C29599 |
| Color/Form: | White glistening hexagonal plates from aqueous alcohol|White crystals | HScode: | 29224995 |
| Categories: | Amino Acids and Derivatives |
| PSA: | 63.32000 | XLogP3: | -1.5 |
| Appearance: | Solid | Density: | 3″>1.14 g/cm3 |
| Melting Point: | 293 °C | Boiling Point: | 122-134 °C @ Press: 2-3 Torr |
| Flash Point: | 90.3ºC | Refractive Index: | 1.463 |
| Water Solubility: | H2O: 22.4 g/L (20 C) | Storage Conditions: | Store at RT. |
| Vapor Pressure: | <1 hPa (20 °C) | Specific rotation: | Specific optical rotation: -10.8 at 25 °C/D (c = 2.2); +15.1 deg at 26 °C/D in 6N HCl (38 mols HCl per mol leucine); +7.6 deg at 20 °C/D in 3N NaOH (30 mols NaOH per mol leucine). Molecular rotation: +21.0 deg at /D (5NHCl); +29.5 deg /D (glacial acetic acid) |
| PKA: | 2.35(at 13 °C) | Henrys Law Constant: | Henry’s Law constant = 3.49X10-9 atm-cu m/mol at 25 °C (est) |
| Dissociation Constants: | 2.35 (at 13 °C)|pKa = 2.35|pKa1 = 2.36 (carboxylic acid); pKa2 = 9.63 (amine) (est) | Collision Cross Section: | 135.16 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|138.71 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|128 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine]|134.8 Ų [M+H]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|130.6 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|132.51 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|135.56 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|131.8 Ų [M-H]- |
| Experimental Properties: | Crystals. Freely soluble in water. /Leucine hydrochloride/|Hydroxyl radical reaction rate constant = 4.23X10-11 cu cm/molec-sec at 25 °C (est) |
Classification of the substance or mixture
Not classified.
GHS label elements, including precautionary statements
| Pictogram(s) | No symbol. |
|---|---|
| Signal word |
No signal word |
| Hazard statement(s) |
none |
| Precautionary statement(s) | |
| Prevention |
none |
| Response |
none |
| Storage |
none |
| Disposal |
none |
Other hazards which do not result in classification
no data available
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.