Vitamin B3 | Nicotinic Acid (CAS 59-67-6) & Niacinamide (CAS 98-92-0) - - PREMIUM INGREDIENT

Vitamin B3 | Nicotinic Acid (CAS 59-67-6) for metabolic wellness | Niacinamide (CAS 98-92-0) for skin wellness

Categories:

Vitamines

CAS No:

3 / 1

Description

Certificates

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Basic Information

Vitamin B3
Product Type	Water-soluble essential B vitamin
Available Forms	Niacin (Nicotinic Acid) Niacinamide (Nicotinamide)
CAS No. (Niacin)	59-67-6
CAS No. (Niacinamide)	98-92-0
E Number	E650
Physical Form	White crystalline powder
Common Specifications	99% min purity

Product Overview

Vitamin B3 is an essential water-soluble vitamin mainly available in two core forms: Nicotinic Acid and Niacinamide, each with distinct functional advantages and application scenarios.

Nicotinic Acid (CAS 59-67-1) is widely applied in food fortification and dietary supplement formulations, focusing on supporting healthy metabolic function and maintaining normal human physiological metabolism.

Niacinamide (CAS 98-92-0), the cosmetic-grade form of Vitamin B3, serves as a popular skincare raw material that helps improve and maintain healthy skin condition. Both forms are high-purity, stable raw materials, widely supplied for food, nutritional and cosmetic industrial formulation needs.

Niacin VS Niacinamide

Comparison Item	Niacin (Nicotinic Acid)	Niacinamide (Nicotinamide)
Main Industry Usage	Primary grade for Food, Beverage, Feed, Supplements	Primary grade for Cosmetics & Skincare Products
Skin Tolerance	Causes obvious skin flushing, redness and stinging when applied topically	Non-flushing, mild and safe for direct skin contact
Food Application	Widely used, mainstream food fortification grade	Allowed for food use, secondary choice in food industry
Cosmetic Application	Rarely used in cosmetics due to irritation risk	Top popular skincare ingredient for barrier repair and brightening
Functional Focus	Energy metabolism, lipid regulation, nutritional fortification	Skin repair, oil control, skin brightening, anti-oxidation
Customer Group Preference	Food factories, feed factories, supplement manufacturers	Cosmetic factories, skincare formula brands

Character

Both nicotinic acid and niacinamide are white crystalline powders with good solubility in water. They are stable under proper sealed storage conditions. Niacinamide is known for its excellent skin compatibility without causing flushing, making it suitable for both oral and topical applications.

Main Functions

1.Essential Nutrient for Energy Metabolism: Both nicotinic acid and niacinamide serve as essential B-vitamin forms supporting energy metabolism in nutritional formulations.

2.Skin Barrier Support (Niacinamide): Niacinamide is widely used in skincare formulations for skin conditioning and barrier support, without the flushing effect associated with high-dose nicotinic acid.

3.No Flushing Form (Niacinamide): Niacinamide provides B3 nutrition without causing skin flushing, making it suitable for both supplement and cosmetic applications.

4.Food Fortification Grade (Nicotinic Acid): Nicotinic acid is suitable for food fortification and dietary supplement formulations as a cost-effective B3 nutrient source.

Applications

1.Dietary Supplements Both nicotinic acid and niacinamide are widely used in tablets, capsules and powder blends as B3 nutrient ingredients. Niacinamide is preferred when flushing needs to be avoided.

2.Cosmetic and Personal Care Mainly uses niacinamide in skincare creams, serums and lotions for skin conditioning. Nicotinic acid is rarely used in cosmetic formulations due to potential skin flushing.

Packaging & Storage

Package: 25kg fiber drum with double inner plastic bags

Storage: Store in cool, dry, ventilated environment, keep tightly sealed

Shelf Life: 24 months under proper storage conditions

Product Name:	Nicotinic acid	Other Name:	3-Pyridinecarboxylic acid;Nicotinic acid;Akotin;Efacin;Niacin;Nicodelmine;Niconacid;Nico-Span;Nicotinipca;Nicyl;β-Pyridinecarboxylic acid;Nicosan 3;Nicacid;Nicangin;Daskil;Linic;Nicolar;3-Carboxylpyridine;3-Carboxypyridine;Pellagrin;Pelonin;Apelagrin;Nyclin;3-Pyridylcarboxylic acid;SR 4390;Niaspan;Enduracin;Slo-niacin;Niacor;Nicobid;Wampocap;Niac;NSC 169454;E 375;CaRo 03;Microvit B3 Promix Niacin;Vitamin B3;NiaShure;Disperse NNO;Bovi-Niacin;Vitamin B3 (niacin);Vitamin B3 (nicotinic acid);Pyridine-3-carboxylic acid;123574-58-3;1580002-26-1
CAS No.:	59-67-6	Molecular Formula:	C6H5NO2
InChIKeys:	InChIKey=PVNIIMVLHYAWGP-UHFFFAOYSA-N	Molecular Weight:	123.10900
Exact Mass:	123.11	EC Number:	200-441-0
HScode:	29362990	Categories:	Vitamins and Minerals Medicines

PSA:	50.19000	XLogP3:	0.77980
Appearance:	Nicotinic acid is an odorless white crystalline powder with a feebly acid taste. pH (saturated aqueous solution) 2.7. pH (1.3% solution) 3-3.5. (NTP, 1992)	Density:	3 @ Temp: 25 °C”>1.473 g/cm3 @ Temp: 25 °C
Melting Point:	236.6 °C	Boiling Point:	166 °C @ Press: 0.6 Torr
Flash Point:	182ºC	Refractive Index:	1.466 (20ºC)
Water Solubility:	H2O: 1000 g/L (20 ºC)	Storage Conditions:	0-6ºC
Vapor Pressure:	5.70X10-6 mm Hg at 25 deg C (est)	Toxicity:	LD50 s.c. in rats: 5 g/kg (Brazda, Coulson)
Explosive limit:	Explosive limits , vol% in air: 25 – ?	Odor:	Odorless
Taste:	Sour taste	PH:	pH = 2.7 (saturated aq soln)
PKA:	4.75(at 25 °C)

Classification of the substance or mixture

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H319 Causes serious eye irritation
Prevention	P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store in an area without drain or sewer access. Separated from strong acids, bases and oxidants.