top of page

Basic Information 

 

Product Name

Calcium Saccharin Anhydrous

(Saccharin Calcium Salt / Hemicalcium Saccharin)

CAS Number 6485-34-3
EINECS Number 229-349-9
E Number E954(iii)
Molecular Formula C₁₄H₈CaN₂O₆S₂
Molecular Weight 404.44
Appearance White crystals or white crystalline powder
Odor & Taste Odorless, intensely sweet; dilute solution ~300–500× sweeter than sucrose
Solubility Sparingly soluble in water; slightly soluble in ethanol
Assay (anhydrous basis) ≥95.0% (FCC); 99.0–101.0% (USP)
Melting Point 226–230 °C
Available Grade Food Grade (FCC); Pharmaceutical Grade (USP / BP / EP)
Executive Standard FCC, USP, BP, EP
HS Code 2925.11
Sodium Content Sodium-free (contains calcium ion instead of sodium ion)

 

Product Overview

Calcium Saccharin is the calcium salt of saccharin, one of the four permitted forms of saccharin (E954) alongside free saccharin, sodium saccharin and potassium saccharin. It is a high-intensity, non-nutritive, zero-calorie sweetener, approximately 300 to 500 times sweeter than sucrose on a weight basis.

Its defining advantage is that it introduces no sodium ions into the formulation. Instead, it delivers sweetness through a divalent calcium ion, making it the preferred choice when developers need to control or reduce sodium intake in the end product. It is widely used in low-sodium food, pharmaceutical oral preparations and oral care products such as toothpaste and mouthwash.

Calcium saccharin is chemically stable over a wide pH range and under heat, does not ferment in the mouth, and is not metabolized by the body — it provides sweetness without calories and without contributing to dental caries.


 

Key Product Characteristics

1.Sodium-free by nature: No sodium ions introduced; ideal for low-sodium / reduced-sodium formula development and sodium-restricted diet products

2.High sweetness intensity: 300–500× sucrose, used at very low dosage, cost-effective per sweetness unit

3.Zero calorie & non-nutritive: Not metabolized by the body, suitable for sugar-free, diet and weight-management products

4.Excellent stability: Heat stable and stable across a broad pH range; survives baking, hot filling and sterilization without decomposition

5.Mild taste profile: Milder metallic bitter aftertaste compared with sodium saccharin, giving a cleaner mouthfeel

6.Non-cariogenic: Not fermented by oral bacteria, does not produce acid or contribute to tooth decay

7.Calcium ion carrier: Delivers a small amount of calcium, a minor plus for oral care and mineral-focused formulations

8.Regulatory approved: Listed as E954(iii) in EU, approved by FDA (21 CFR 180.37), compliant with FCC / USP / BP / EP


 

Main Functions

1. High-intensity Sweetening: Delivers 300–500 times the sweetness of sucrose at a fraction of the dosage, replacing sugar in zero-calorie and reduced-sugar products without adding calories or carbohydrates.

2. Sodium-free Sweetness Delivery: Provides sweet taste without introducing sodium ions, enabling low-sodium and sodium-free product claims — a unique advantage over sodium saccharin in formulations targeting hypertension-conscious consumers and medical nutrition.

3. Bitterness & Astringency Masking: Masks the bitter, astringent or unpleasant taste of active ingredients such as fluoride, antiseptics, herbal extracts, drugs and vitamins, improving palatability and patient / consumer acceptance.

4. Stability Across Processing Conditions: Withstands high-temperature processing (baking, hot filling, sterilization) and remains stable over a wide pH range, retaining sweetness throughout product shelf life.

5. Non-cariogenic Oral Sweetening: Not fermented by oral bacteria, does not lower plaque pH, and does not contribute to tooth decay — making it suitable for oral care and sugar-free confectionery where dental health is a claim.

6. Calcium Ion Contribution: The calcium counterion provides a small amount of dietary calcium, complementing enamel remineralization and mineral-supplement positioning.


 

Application Scope

Oral Care & Personal Care: Toothpaste (regular, whitening, desensitizing and children’s toothpaste), mouthwash and mouth rinse, dental floss coating, chewing gum, breath strips and lip care products.

Pharmaceutical & Healthcare: Chewable tablets, lozenges and throat pastilles, oral syrups and suspensions, dry powder syrups, vitamin and mineral effervescent tablets, antacid suspensions, and medications for sodium-restricted patients.

Food & Beverage: Diet and sugar-free beverages, tabletop sweeteners, sugar-free confectionery and hard candy, jams and jellies, baked goods, dairy desserts, and low-sodium functional / medical nutrition products.

Other Applications: Veterinary and animal feed palatability, and specialty electroplating brightener formulations.


Packaging & Storage

Packaging: 25kg fiber drum / kraft paper bag with PE inner liner; palletized and stretch-wrapped available

Storage Condition: Store in cool, dry, ventilated warehouse. Keep tightly sealed, away from moisture, direct sunlight, heat and odor sources.

Shelf Life: 24 months under sealed, dry storage conditions from production date

m toxic and odorous substances.

Product Name: 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, calcium salt, hydrate (4:2:7) Other Name: 1,2-Benzisothiazol-3(2H)-one,1,1-dioxide,calcium salt,hydrate (4:2:7);1,2-Benzisothiazol-3(2H)-one,1,1-dioxide,calcium salt,hydrate (4:7);Calcium 1,2-benzisothiazolin-3-one 1,1-dioxide hydrate;Calcium o-benzolsulfimide hydrate;Calcium saccharin hydrate
CAS No.: 6381-91-5 Molecular Formula: C7H5NO3S.1/2Ca.7/4H2O
InChIKeys: InChIKey=FJCBEDPGTMUUQL-UHFFFAOYSA-N Molecular Weight: 934.97
Exact Mass: 421.95600 EC Number: 229-349-9
DSSTox ID: DTXSID5047459 HScode: 2925110000
Categories: Sweeteners

PSA: 134.89000 XLogP3: 2.56390
Boiling Point: 438.9ºC at 760 mmHg Flash Point: 219.3ºC
Storage Conditions: room temp

Classification of the substance or mixture

Acute toxicity – Category 4, Oral

Acute toxicity – Category 4, Dermal

Acute toxicity – Category 4, Inhalation

GHS label elements, including precautionary statements

Pictogram(s)
Signal word

Warning

Hazard statement(s)

H302 Harmful if swallowed

H312 Harmful in contact with skin

H332 Harmful if inhaled

Precautionary statement(s)
Prevention

P264 Wash … thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/…

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response

P301+P317 IF SWALLOWED: Get medical help.

P330 Rinse mouth.

P302+P352 IF ON SKIN: Wash with plenty of water/…

P317 Get medical help.

P321 Specific treatment (see … on this label).

P362+P364 Take off contaminated clothing and wash it before reuse.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

Storage

none

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.