NAC N-Acetyl-L-Cysteine-CAS No:616-91-1 supplier - - PREMIUM INGREDIENT

NAC N-Acetyl-L-Cysteine CAS 616-91-1 | amino acid for food and pharma

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Amino acids

CAS No:

616-91-1

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Description

Certificates

Basic Info

Characteristics

Hazard Identification

Handling and Storage

Product Detail

N‑Acetyl‑L‑Cysteine (NAC) is an acetylated derivative of L‑cysteine and classified into amino acid. It is widely applied in both pharmaceutical and food industries.

Due to its thiol functional group, N‑Acetyl‑L‑Cysteine acts as a mucolytic agent by reducing the viscosity of mucus, making it easier to clear respiratory secretions. It is also used in pharmaceutical formulations for its antioxidant properties and stabilizing effects on certain active ingredients. Meanwhile, it serves as a nutritional ingredient in food and dietary supplement fields.

Key Properties

Chemical Name: N-Acetyl-L-Cysteine
CAS Number: 616-91-1
Molecular Formula: C₅H₉NO₃S
Molecular Weight: 163.19
Quality Standards: AJI, USP
Solubility: Soluble in water
Storage: Store in a cool, dry place, protected from light and moisture

Applications

1. Pharmaceutical Industry

N‑Acetyl‑L‑Cysteine is mainly used in pharmaceutical applications. As a mucolytic agent, it helps reduce mucus viscosity and improve airway clearance in patients with chronic respiratory conditions such as chronic bronchitis, asthma, and other pulmonary disorders.

It may also be used as an antioxidant and stabilizing agent in certain pharmaceutical preparations, including oral formulations, injectable products, and specialized drug delivery systems.

2. Food & Dietary Supplement Industry

As a food‑grade raw material, N‑Acetyl‑L‑Cysteine is used in dietary supplements and functional food products. It works as an antioxidant to protect food ingredients from oxidative deterioration, and is applied in nutritional formula products. It can be used as a nutritional additive in compliance with relevant food regulatory requirements.

3. Biopharmaceutical & Research Applications

In biopharmaceutical research and development, NAC is used in cell culture media, protein stabilization, and experimental antioxidant studies. Its thiol group makes it useful in biochemical and pharmaceutical development processes.

4. Other Industrial Applications

N‑Acetyl‑L‑Cysteine may also be used in high‑end cosmetic formulations and specialty industrial applications where antioxidant performance is required. However, its primary application remains in the pharmaceutical and food fields.

Product Features

Pharmaceutical-grade raw material
Well-established active ingredient in respiratory preparations
Mucolytic and antioxidant properties
Suitable for API, intermediate, and formulation use
Complies with AJI and USP quality standards
Supported by ISO, HALAL, KOSHER, BRC, and HACCP related documentation

CERTIFICATE OF ANALYSIS

Product: N-Acetyl-L-Cysteine CAS No: (616-91-1) Quantity: 1000kg Lot No: Date: OCT 25, 2024
Item	Specification	Result
Appearance	White crystals or crystalline powder	Conforms
Identification	Infrared Absorption	Conforms
Specific rotation [ α]D20	+21.3 °to +27.0 °	+23.0 °
State of solution (Transmittance)	Clear and colorless Not less than 98.0%	99.7%
Chloride(Cl)	Not more than 0.04%	<0.04%
Ammonium(NH4)	Not more than 0.02%	<0.02%
Sulfate(SO4)	Not more than 0.03%	<0.03%
Iron (Fe)	Not more than 20ppm	<20ppm
Heavy metals (Pb)	Not more than 10ppm	<10ppm
Arsenic (As2O3)	Not more than 1ppm	<1ppm
Other amino acids	Chromatographically not detectable	Conforms
Loss on Drying	Not more than 0.5%	0.08%
Residue on ignition (sulfated)	Not more than 0.20%	0.1%
Assay	98.5 to 101.0% (Calculated on the dried basis)	99.8%
pH	2.0 to 2.8	2.2
Melting point	106 to 110℃	Conforms

Conclusion: Agree with the specification of AJI92.

Product Name:	N-Acetyl-L-cysteine	Other Name:	L-Cysteine,N-acetyl-;Cysteine,N-acetyl-,L-;N-Acetyl-L-cysteine;N-Acetylcysteine;Acetylcysteine;Mercapturic acid;Mucomyst;Mercapturic acid,(R)-;Airbron;Fluimucil;Fluimucetin;Respaire;Mucolyticum-Lappe;L-Acetylcysteine;Parvolex;Mucolytikum Lappe;Broncholysin;NSC 111180;Broncholysin (mucolytic);Mucosolvin;N-Acetyl-(R)-cysteine;Mucofilin;L-N-Acetylcysteine;Fluimicil;Fluimicil Infantil;Fluibiotic;Nα-Acetylcysteine;Exomuc;(R)-N-Acetylcysteine;Tixair;Muco Sanigen;Brunac;Fluatox;Mucocedyl;Mucolator;Neo-Fluimucil;Fabrol;Mucolyticum;Mucret;Fluprowit;Acetilcysteina;ACC;Flumil;Syntemucol;Hypotears;Lysomucil;Fluimucil Antidot;Acetadote;Mucosten;Asist;Trom;Mentopin;Mucomelt;Mucinac;(2R)-2Acetamido-3-sulfanylpropanoic acid;Cysteplus;Ac-Cys-OH;(2R)-2-Acetamido-3-sulfanylpropanoic acid;7696-05-1;1261105-20-7
CAS No.:	616-91-1	Molecular Formula:	C5H9NO3S
InChIKeys:	InChIKey=PWKSKIMOESPYIA-BYPYZUCNSA-N	Molecular Weight:	163.19
Exact Mass:	163.19	BRN:	1724426
EC Number:	210-498-3	UNII:	WYQ7N0BPYC
DSSTox ID:	DTXSID5020021	NCI Thesaurus Code:	C200
Color/Form:	Crystals from water\|WHITE, CRYSTALLINE POWDER	ATC Code:	R05CB01\|R – Respiratory system\|S – Sensory organs\|V – Various
HScode:	29309016	Categories:	Amino Acids and Derivatives

PSA:	67.4	XLogP3:	0.4
Appearance:	White Solid	Density:	1.3±0.1 g/cm3
Melting Point:	109.5 °C	Boiling Point:	407.7°C at 760 mmHg
Flash Point:	200.4±27.3 °C	Refractive Index:	1.519
Water Solubility:	soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether.H2O: 100 mg/mL with heating	Storage Conditions:	2-8°C
Vapor Pressure:	1.1X10-5 mm Hg at 25 deg C /Estimated/	Toxicity:	Oral-rat LD50:5050 mg/kg; Oral-Mouse LD50:7888 mg/kg
Flammability characteristics:	Decomposes smoke in humid air; burning releases toxic nitrogen oxide and sulfur oxide smoke	Specific rotation:	-35.1 ºC (c=2,H2O)
Odor:	SLIGHT ACETIC ODOR	Taste:	CHARACTERISTIC SOUR TASTE
PH:	2 TO 2.75 (1 IN 100 ML)	PKA:	9.52(at 25 °C)
Henrys Law Constant:	Henry’s Law constant = 1.7X10-13 atm-cu m/mole at 25 °C /Estimated/	Dissociation Constants:	9.52 (at 25 °C)\|pKa= 3.24 (carboxylic acid moiety)\|pKa = 9.52 (SH group)
Collision Cross Section:	140.9 Å² [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]\|140.9 Å² [M+Na]+	Experimental Properties:	It is stable in ordinary light, nonhygroscopic (oxidizes in moist air), and stable at temperatures up to 120 °C\|Hydroxyl radical reaction rate constant = 5.5X10-11 cu cm/molec-sec at 25 °C /Estimated/

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Unopened vials of acetylcysteine sodium solution should be stored at 15-30 deg C. Following exposure to air, solutions should be stored at 2-8 deg C to retard oxidation and should be used within 96 hr.