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Basic Information

 

N-Acetyl-L-Cysteine (NAC)
CAS Number 616-91-1
Standard Compliance USP, CP, AJI
Available Certifications HALAL, KOSHER, ISO
Appearance White crystalline powder
Purity 98% Min
Solubility Easily soluble in water
Storage Condition Sealed, dry and cool place, avoid direct sunlight

 

Product Overview

N-Acetyl-L-Cysteine, Cas No.: 616-91-1,  commonly abbreviated as NAC, is a highly bioavailable acetylated derivative of L-cysteine, featuring stable chemical properties and powerful biological activity. As an essential precursor for endogenous glutathione synthesis in the human body, NAC occupies an irreplaceable core position in health nutrition and industrial application fields. It possesses excellent antioxidant and physiological regulation capabilities, making it a versatile functional amino acid raw material. With mature industrial production technology, high purity and stable batch consistency, NAC has formed a huge global market demand system covering pharmaceutical manufacturing, nutritional health products, food industry and biotechnological research, and has become one of the most popular functional amino acid additives in the international market.

Character

N-Acetyl-L-Cysteine is a white crystalline powdery substance with good water solubility and no peculiar odor. Compared with ordinary L-cysteine, the acetylation modification greatly improves its stability, bioavailability and oxidation resistance, effectively avoiding deterioration and activity loss during storage and processing. The product strictly complies with USP and CP quality specifications. It has good compatibility with various food raw materials, nutritional formulations and pharmaceutical intermediates, does not produce adverse chemical reactions, and features high safety, strong practicability and wide adaptability for industrial and nutritional applications.

Main Functions

1.Boost Endogenous Antioxidant Synthesis:  NAC acts as a critical precursor for glutathione production in the human body. Glutathione is the core antioxidant substance of cellular defense system, which can effectively scavenge free radicals, reduce oxidative stress damage to cells, delay cellular aging, and protect the stability of human tissue and organ functions.

2.Support Liver Detoxification & Hepatic Health:  It assists the liver in metabolizing harmful toxins and metabolic wastes, reduces the burden of liver metabolism, protects liver cells from oxidative damage and chemical stimulation, and maintains normal liver physiological functions and detoxification metabolism.

3.Maintain Respiratory System Health:  NAC has excellent mucolytic and respiratory protection properties, which can dilute viscous secretions in the respiratory tract, relieve respiratory discomfort, protect lung and bronchial tissues from external pollution and oxidative irritation, and support daily respiratory health maintenance.

4.Maintain Human Physiological Balance:  It participates in human amino acid metabolism and protein synthesis regulation, stabilizes internal environmental balance, improves cellular metabolic activity, enhances body antioxidant defense capability, and maintains the normal operation of human physiological functions.

5.Food Antioxidation & Quality Preservation:  In food processing, NAC can inhibit enzymatic browning and oxidative deterioration of food raw materials, delay food spoilage, maintain food color, flavor and nutritional stability, and extend the shelf life of processed food products.

 

Applications 

1. Pharmaceutical Industry: Used in respiratory medicines and clinical detox preparations. It works as a mucolytic agent to thin mucus and assist detoxification.

2. Dietary Supplement & Functional Food: Added into nutritional capsules and powder supplements. It serves as glutathione precursor to deliver antioxidant support, maintain liver health and support respiratory wellness.

3. Food Industry Fortification & Processing: Applied in grain and beverage processing. It inhibits oxidative browning to retain food color and nutrition, and supplements cysteine for functional food formulas.

4. Biotech & Cell Culture Medium: Used in cell and microbial culture media. It supplies amino acid nutrition and provides antioxidant protection for cell growth.

Packaging and Storage

packaging: 25kg/  drum with inner plastic vacuum bag.

Storage: Store in a dry, cool and ventilated warehouse, keep sealed and away from high temperature and direct sunlight to ensure long-term stable product quality.

 

 

 

 CERTIFICATE OF ANALYSIS

Product:  N-Acetyl-L-Cysteine                                                                      CAS No: (616-91-1)

Quantity: 1000kg

Lot No:                                                                                                         Date:     OCT 25, 2024

Item 

Specification 

Result 

Appearance

White crystals or crystalline powder

Conforms

Identification

Infrared Absorption

Conforms

Specific rotation [ α]D20

+21.3 °to +27.0 °

+23.0 °

 

State of solution (Transmittance)

Clear and colorless

Not less than 98.0%

99.7%

 Chloride(Cl)

Not more than 0.04%

<0.04%

 Ammonium(NH4)

Not more than 0.02%

<0.02%

 Sulfate(SO4)

Not more than 0.03%

<0.03%

 Iron (Fe)

Not more than 20ppm

<20ppm

 Heavy metals (Pb)

Not more than 10ppm

<10ppm

Arsenic (As2O3)

Not more than 1ppm

<1ppm

Other amino acids

Chromatographically

not detectable

Conforms

Loss on Drying

Not more than 0.5%

0.08%

Residue on ignition (sulfated)

Not more than 0.20%

0.1%

 Assay

98.5 to 101.0%

(Calculated on the dried basis)

99.8%

pH

2.0 to 2.8

2.2

 Melting point

106 to 110℃

Conforms

 

Conclusion: Agree with the specification of AJI92.

 

Product Name: N-Acetyl-L-cysteine Other Name: L-Cysteine,N-acetyl-;Cysteine,N-acetyl-,L-;N-Acetyl-L-cysteine;N-Acetylcysteine;Acetylcysteine;Mercapturic acid;Mucomyst;Mercapturic acid,(R)-;Airbron;Fluimucil;Fluimucetin;Respaire;Mucolyticum-Lappe;L-Acetylcysteine;Parvolex;Mucolytikum Lappe;Broncholysin;NSC 111180;Broncholysin (mucolytic);Mucosolvin;N-Acetyl-(R)-cysteine;Mucofilin;L-N-Acetylcysteine;Fluimicil;Fluimicil Infantil;Fluibiotic;Nα-Acetylcysteine;Exomuc;(R)-N-Acetylcysteine;Tixair;Muco Sanigen;Brunac;Fluatox;Mucocedyl;Mucolator;Neo-Fluimucil;Fabrol;Mucolyticum;Mucret;Fluprowit;Acetilcysteina;ACC;Flumil;Syntemucol;Hypotears;Lysomucil;Fluimucil Antidot;Acetadote;Mucosten;Asist;Trom;Mentopin;Mucomelt;Mucinac;(2R)-2Acetamido-3-sulfanylpropanoic acid;Cysteplus;Ac-Cys-OH;(2R)-2-Acetamido-3-sulfanylpropanoic acid;7696-05-1;1261105-20-7
CAS No.: 616-91-1 Molecular Formula: C5H9NO3S
InChIKeys: InChIKey=PWKSKIMOESPYIA-BYPYZUCNSA-N Molecular Weight: 163.19
Exact Mass: 163.19 BRN: 1724426
EC Number: 210-498-3 UNII: WYQ7N0BPYC
DSSTox ID: DTXSID5020021 NCI Thesaurus Code: C200
Color/Form: Crystals from water|WHITE, CRYSTALLINE POWDER ATC Code: R05CB01|R – Respiratory system|S – Sensory organs|V – Various
HScode: 29309016 Categories: Amino Acids and Derivatives

PSA: 67.4 XLogP3: 0.4
Appearance: White Solid Density: 1.3±0.1 g/cm3
Melting Point: 109.5 °C Boiling Point: 407.7°C at 760 mmHg
Flash Point: 200.4±27.3 °C Refractive Index: 1.519
Water Solubility: soluble in water, ethanol, methanol, dimethyl sulfoxide, hot isopropyl alcohol, methyl acetate and ethyl acetate. Insoluble in chloroform and ether.H2O: 100 mg/mL with heating Storage Conditions: 2-8°C
Vapor Pressure: 1.1X10-5 mm Hg at 25 deg C /Estimated/ Toxicity: Oral-rat LD50:5050 mg/kg; Oral-Mouse LD50:7888 mg/kg
Flammability characteristics: Decomposes smoke in humid air; burning releases toxic nitrogen oxide and sulfur oxide smoke Specific rotation: -35.1 ºC (c=2,H2O)
Odor: SLIGHT ACETIC ODOR Taste: CHARACTERISTIC SOUR TASTE
PH: 2 TO 2.75 (1 IN 100 ML) PKA: 9.52(at 25 °C)
Henrys Law Constant: Henry’s Law constant = 1.7X10-13 atm-cu m/mole at 25 °C /Estimated/ Dissociation Constants: 9.52 (at 25 °C)|pKa= 3.24 (carboxylic acid moiety)|pKa = 9.52 (SH group)
Collision Cross Section: 140.9 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]|140.9 Ų [M+Na]+ Experimental Properties: It is stable in ordinary light, nonhygroscopic (oxidizes in moist air), and stable at temperatures up to 120 °C|Hydroxyl radical reaction rate constant = 5.5X10-11 cu cm/molec-sec at 25 °C /Estimated/

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

Other hazards which do not result in classification

no data available

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Unopened vials of acetylcysteine sodium solution should be stored at 15-30 deg C. Following exposure to air, solutions should be stored at 2-8 deg C to retard oxidation and should be used within 96 hr.