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  CHOLINE CHLORIDE  

 

Choline Chloride classified as one of water-soluble B-complex vitamins (formerly referred as vitamin B4 in some publications). Choline chloride is a white, water-soluble salt, widely used in feed and food.

 

Uses: 

 

 A: In feed

 

Choline chloride is an important additive in feed especially for chickens where it accelerates growth.

 

B: In nutriton

 

As a component of phospholipid, it maintains the normal metabolism of cell and improves the transport and synthesis of fat.

As a precursor of synthesis of acetylcholine, it plays important roles in neurotransmission.

As a donator of methyl groups, it participates in numerous biological processes

 

C: In pharmaceutical field

 

Choline chloride was nominated for oral and intravenous use.

 

oral choline chloride is used in liver disease including chronic hepatitis and cirrhosis, hypercholesterolemia, depression ,memory loss, Alzheimer’s disease and dementia; schizophrenia; body building delaying fatigue in endurance sports preventing neural tube defects; preventing cancer; Huntington’s chorea Tourette’s disease cerebellar ataxia complex partial seizures asthma and as a supplement in infant formulas.

 

Intravenously choline chloride is used for TPN associated hepatic steatosis, choline deficiency, and fetal alcohol syndrome.

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Items Specifications
Content ≧98.0%
Loss on drying ≤5.0%
Heavy metal ≤0.001%
Arsenic ≤0.0002%

Product Name: Choline chloride Other Name: Ethanaminium,2-hydroxy-N,N,N-trimethyl-,chloride (1:1);Choline,chloride;Ethanaminium,2-hydroxy-N,N,N-trimethyl-,chloride;Biocolina;Hepacholine;(2-Hydroxyethyl)trimethylammonium chloride;Lipotril;Cholinium chloride;(β-Hydroxyethyl)trimethylammonium chloride;Bilineurin chloride;Luridin chloride;Biocoline;Hormocline;Neocolina;Paresan;Trimethyl(2-hydroxyethyl)ammonium chloride;Actiron CC 6;Choline chloride;Norcol 25;COL 24;ReaShure Choline;Claytreat;(2-Hydroxyethyl)trimethylazanium chloride;1643859-93-1;2028303-08-2
CAS No.: 67-48-1 Molecular Formula: C5H14NO.Cl
InChIKeys: InChIKey=SGMZJAMFUVOLNK-UHFFFAOYSA-M Molecular Weight: 139.624
Exact Mass: 139.076 EC Number: 200-655-4
UNII: 45I14D8O27 ICSC Number: 0853
NSC Number: 758473|402838 DSSTox ID: DTXSID4020325
Color/Form: WHITE CRYSTALS|Deliquescent crystals HScode: 2923100000
Categories: Feed Additive

PSA: 20.23 XLogP3: log Kow = -5.16 (est)
Appearance: White crystalline powder Density: 1.205 g/cm3
Melting Point: 305 °C (decomp) Water Solubility: H2O: soluble
Storage Conditions: 0-6ºC Toxicity: LD50 in rats (g/kg): 0.400 i.p.; 6.64 orally (Hartung, Cornish)
PH: 4.7 (10% SOLN IN WATER) Collision Cross Section: 121 Ų [M]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties: Aq soln is practically neutral Air and Water Reactions: Deliquescent. Very soluble in water. (NTP, 1992)
Reactive Group: Alcohols and Polyols Reactivity Profile: Choline chloride is a quaternary ammonium salt. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Quaternary ammonium salts often serve as catalysts in reactions. They are incompatible with many strong oxidizers and reducing agents, such as metal hydrides, alkali/active metals, and organometallics. Unlike the ammonium ion, [NH4]+, and the primary, secondary, or tertiary ammonium cations, the quaternary ammonium cations are permanently charged, independent of the pH of their solution.

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Pictogram(s) No symbol.
Signal word

No signal word

Hazard statement(s)

none

Precautionary statement(s)
Prevention

none

Response

none

Storage

none

Disposal

none

Other hazards which do not result in classification

no data available

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong oxidants.