Basic Information
| Item | Specification |
|---|---|
| Product Name | 5-Hydroxytryptophan (5-HTP), L-5-Hydroxytryptophan |
| CAS No. | 4350-09-8 |
| Molecular Formula | C₁₁H₁₂N₂O₃ |
| Molecular Weight | 220.23 g/mol |
| IUPAC Name | (S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid |
| Appearance | White to off-white crystalline powder |
| Assay (HPLC) | ≥99.0% |
| Melting Point | 270℃ (decomposition) |
| Specific Rotation | -28.0° ~ -32.0° |
| Solubility | Freely soluble in water, slightly soluble in ethanol |
| Isoelectric Point | 5.89 |
| Stability | Light-sensitive, stable under pH 4–7, avoid high temperature |
| Application Grade | Nutraceutical / Dietary supplement grade |
Product Overview
5-Hydroxytryptophan (5-HTP) is a key natural amino acid and direct precursor for serotonin synthesis in human body. As a premium raw material for dietary supplements, it is widely formulated to support balanced mood and healthy sleep quality, as well as assist appetite regulation. 5-HTP is highly favored by nutraceutical manufacturers for its clear physiological mechanism and reliable purity, and it is commonly used to produce capsules, tablets and powder blends for wellness formulas.
Character
1.White to off-white fine crystalline powder, uniform particle size.
2.Good water solubility and excellent powder flowability, convenient for capsule filling, tableting and powder blending.
3.High purity with low related impurities, stable quality under proper storage conditions.
4.Light-sensitive, avoid prolonged exposure to strong light.
Function
1.Acts as the direct precursor of serotonin, supporting serotonin synthesis in human body.
2.Helps maintain balanced mood and ease daily stress.
3.Supports healthy sleep cycle and improves sleep quality.
4.Assists in regulating appetite.
Application
1.Primary application: Raw material for dietary supplements and nutraceutical formulations.
2.Mood balance & stress relief supplement capsules, tablets
3.Healthy sleep support dietary supplements
4.Appetite management & wellness powder blends
5.Functional health formulations
Packaging and Storage
Packaging: 25kg per fiber drum, with double inner PE bags. Custom package available.
Storage: Keep container tightly closed. Store in cool, dry and ventilated place. Protect from strong light and high temperature.
Shelf Life: 24 months under proper storage.
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Product Name: L-5-HydroxytryptophanOther Name:5-hydroxy-l-tryptopha;pretonine;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HYDROXYTRYPTOPHAN HYDRATE;L-5-HYDROXYTRYPTOPHAN;2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPIONIC ACID;(-)-5-HYDROXY-L-TRYPTOPHAN;5-HYDROXY-L-TRP-OHCAS No.: 4350-09-8Molecular Formula: C11H12N2O3InChIKeys: LDCYZAJDBXYCGN-VIFPVBQESA-NMolecular Weight: 220.22Exact Mass: 220.22BRN: 88200EC Number: 224-411-1UNII: C1LJO185Q9UN Number: 2811TSCA: TSCA listedDSSTox ID: DTXSID1025437NCI Thesaurus Code: C52181Color/Form: whiteATC Code: N – Nervous systemHScode: 29339990Categories: Amino Acids and Derivatives
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PSA: 99.3XLogP3: -2.051Appearance: white solidDensity: 0.902 g/mL at 25 °C (lit.)Melting Point: 270 °C (dec.) (lit.)Boiling Point: 361.16°C (rough estimate)Flash Point: 175 °FRefractive Index: n20/D1.4850(lit.)Water Solubility: Slightly solubleStorage Conditions: 2-8°C
Vapor Pressure:
2.55X10-11 mm Hg at 25 deg C (est)
Specific rotation: -32.5 º (c=1,H2O on dry basis)PKA: 2.22±0.10(Predicted)Henrys Law Constant: Henry’s Law constant = 2.1X10-18 atm-cu m/mol at 25 °C (est)Collision Cross Section: 152.2 Ų [M+Na]+ [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|148.86 Ų [M-H]- [CCS Type: DT, Method: single field calibrated with Agilent tune mix (Agilent)]|157.88 Ų [M+H]+ [CCS Type: DT, Method: stepped-field]|156.47 Ų [M+Na]+ [CCS Type: DT, Method: stepped-field]|153.72 Ų [M-H]- [CCS Type: DT, Method: stepped-field]|149.8 Ų [M-2H+Na]-Experimental Properties:Hydroxyl radical reaction rate constant = 2.39X10-10 cu cm/molec-sec at 25 °C (est)|Crystals; specific optical rotation: -32.5 deg at 20 °C/D (water); +16.0 deg at 20 °C/D (4 N HCl) /l-form/|Crystals; specific optical rotation: +32.2 deg at 20 °C/D (water) /d-form/Air and Water Reactions:
L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .
Reactive Group: Phenols and CresolsReactivity Profile: L-5-Hydroxytryptophan reacts with bases. .Critical Temperature & Pressure:
Classification of the substance or mixture
Acute toxicity – Category 3, Oral
GHS label elements, including precautionary statements
| Pictogram(s) |  |
|---|---|
| Signal word |
Danger |
| Hazard statement(s) |
H301 Toxic if swallowed |
| Precautionary statement(s) | |
| Prevention |
P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. |
| Response |
P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see … on this label). P330 Rinse mouth. |
| Storage |
P405 Store locked up. |
| Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
Other hazards which do not result in classification
no data available
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.